School of Medicine, University of Eastern Finland, Kuopio, Finland.
Department of Medicine, Kuopio University Hospital, Kuopio, Finland.
Lupus. 2021 Jan;30(1):165-171. doi: 10.1177/0961203320967102. Epub 2020 Oct 22.
The objective of the study was to examine the risk of other morbidities among patients with systemic lupus erythematosus (SLE). A total of 1006 adult new-onset SLE patients were identified during 1.1.2000- 31.12.2014 from the register of Social Insurance Institution. For each case three general population controls matched according to age, sex and place of residence at the index day were sampled from the population register. Both groups were followed up from the index date until the end of 2017 or until death. The national register on specialized care was explored to gather broadly their 12 organ-specific morbidities, which were found among 91.2% of SLE patients and 66.7% of comparators. The rate ratio (RR) was elevated in almost all disease groups. Musculoskeletal, cardiovascular and genitourinary conditions were the most common comorbidities with RRs of 1.82 (1.68 to 1.97), 1.91 (1.76 to 2.08) and 1.91 (1.73 to 2.09), respectively. Men with SLE had a significantly higher risk for diseases of the genitourinary system and endocrine, nutritional and metabolic diseases compared to women with SLE. The risk of concurrent morbidities is essential to note in the care of SLE patients.
本研究旨在探讨系统性红斑狼疮（SLE）患者发生其他合并症的风险。我们从社会保险机构的登记处确定了 2000 年 1 月 1 日至 2014 年 12 月 31 日期间的 1006 例成年新发 SLE 患者。对于每个病例，我们从人口登记处按年龄、性别和居住地点与指数日匹配了 3 名普通人群对照。两组均从指数日期开始随访，直至 2017 年底或直至死亡。我们还探索了全国专门护理登记处，以广泛收集 SLE 患者（占 91.2%）和对照组（占 66.7%）中发现的 12 种器官特异性合并症。几乎所有疾病组的率比（RR）均升高。肌肉骨骼、心血管和泌尿生殖系统疾病是最常见的合并症，RR 分别为 1.82（1.68 至 1.97）、1.91（1.76 至 2.08）和 1.91（1.73 至 2.09）。与 SLE 女性患者相比，SLE 男性患者发生泌尿生殖系统疾病和内分泌、营养和代谢疾病的风险显著更高。在 SLE 患者的护理中，注意并发合并症的风险至关重要。
