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丹麦灵活坚定社区治疗的效果:一项准实验对照研究。

The effect of flexible assertive community treatment in Denmark: a quasi-experimental controlled study.

机构信息

Copenhagen Research Center for Mental Health (CORE), Mental Health Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.

Copenhagen Research Center for Mental Health (CORE), Mental Health Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark; University of Copenhagen, Department of Public Health, Section of Epidemiology, Copenhagen, Denmark.

出版信息

Lancet Psychiatry. 2021 Jan;8(1):27-35. doi: 10.1016/S2215-0366(20)30424-7. Epub 2020 Oct 19.

Abstract

BACKGROUND

Flexible assertive community treatment (FACT) is a community-based treatment model for patients with severe mental illness that has been widely implemented despite little evidence for its effectiveness. We aimed to evaluate the effect of FACT on mental health care outcomes compared with treatment from standard community mental health teams (CMHTs) or assertive community treatment (ACT) teams in Denmark.

METHODS

We did a quasi-experimental, propensity-score matched, controlled study in five FACT teams, four ACT teams, and five CMHTs in the Capital Region of Denmark. The FACT teams were established on May 1, 2016 (the index date). Patients were identified through the Danish Psychiatric Register and the study population consisted of all patients receiving care from any of these teams on the index date. Assignment to treatment was based on administrative considerations and was not done by the researchers. Patient data were collected from Danish registers. The primary outcome was analysed in the intention-to-treat population and compared mental health care outcomes (psychiatric admissions and bed days, outpatient contacts, self-harm, coercion, and death by any cause) for patients under the care of CMHTs or ACT teams that were reconfigured to FACT teams (CMHT-FACT or ACT-FACT) with patients who remained under the care of CMHTs and ACT teams. Patients who received FACT were matched using propensity scores with control patients from CMHTs and ACT teams to balance differences in baseline characteristics.

FINDINGS

On May 1, 2016, 2034 individuals (887 in the CMHT-FACT group, 887 in the matched CMHT group, 130 in the ACT-FACT group, 130 in the matched ACT group) were enrolled and were followed up from Nov 1, 2016, to Nov 1, 2018. The number of outpatient contacts was higher for patients receiving FACT than for those in the control groups (CMHT-FACT vs CMHT: incidence rate ratio 1·15; 95 % CI 1·10-1·20; ACT-FACT vs ACT: 1·15; 1·03-1·29). Patients receiving FACT had fewer admissions than those in the control groups (CMHT-FACT vs CMHT: 0·84; 0·76-0·92; ACT-FACT vs ACT: 0·71; 0·59-0·85). However, there were no significant differences in total inpatient days, use of coercion, episodes of self-harm, or deaths.

INTERPRETATION

To our knowledge, this is the first study to investigate the effect of FACT compared with treatment from a CMHT or ACT team. Our results suggest that FACT can provide a more intensive approach in terms of increased outpatient contacts than CMHT care or ACT. FACT requires further evaluation through randomised controlled trials that include a cost-effectiveness component before wider implementation.

FUNDING

Mental Health Services in the Capital Region of Denmark.

摘要

背景

灵活果断社区治疗(FACT)是一种针对严重精神疾病患者的基于社区的治疗模式,尽管其有效性证据有限,但已在广泛实施。我们旨在评估 FACT 与丹麦标准社区精神卫生团队(CMHT)或果断社区治疗(ACT)团队的精神卫生保健结果的效果。

方法

我们在丹麦首都大区的五个 FACT 团队、四个 ACT 团队和五个 CMHT 中进行了一项准实验性、倾向评分匹配、对照研究。FACT 团队于 2016 年 5 月 1 日(基准日)成立。通过丹麦精神病学登记处确定患者,并将所有在基准日接受任何这些团队护理的患者纳入研究人群。治疗分配基于行政考虑,不由研究人员进行。患者数据从丹麦登记处收集。主要结局在意向治疗人群中进行分析,并比较 CMHT 或 ACT 团队改组为 FACT 团队(CMHT-FACT 或 ACT-FACT)后接受治疗的患者与继续接受 CMHT 和 ACT 团队护理的患者的精神保健结果(精神科入院和住院天数、门诊接触、自残、强制和任何原因导致的死亡)。使用倾向评分对接受 FACT 的患者进行匹配,以与 CMHT 和 ACT 团队的对照患者进行匹配,以平衡基线特征的差异。

结果

2016 年 5 月 1 日,共有 2034 人(CMHT-FACT 组 887 人、CMHT 匹配组 887 人、ACT-FACT 组 130 人、ACT 匹配组 130 人)入组,并从 2016 年 11 月 1 日随访至 2018 年 11 月 1 日。接受 FACT 的患者的门诊接触次数高于对照组(CMHT-FACT 与 CMHT:发病率比 1.15;95%CI 1.10-1.20;ACT-FACT 与 ACT:1.15;1.03-1.29)。接受 FACT 的患者入院次数少于对照组(CMHT-FACT 与 CMHT:0.84;0.76-0.92;ACT-FACT 与 ACT:0.71;0.59-0.85)。然而,住院总天数、使用强制、自残发作或死亡没有显著差异。

解释

据我们所知,这是第一项比较 FACT 与 CMHT 或 ACT 团队治疗效果的研究。我们的结果表明,与 CMHT 护理或 ACT 相比,FACT 可以提供更密集的门诊接触方式。在更广泛实施之前,FACT 需要通过包括成本效益部分的随机对照试验进一步评估。

资金

丹麦首都大区精神卫生服务。

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