不同类型的奇异变形杆菌菌株具有IgA蛋白酶活性。

Proteus mirabilis strains of diverse type have IgA protease activity.

作者信息

Senior B W, Albrechtsen M, Kerr M A

机构信息

Department of Medical Microbiology, Dundee University Medical School, Ninewells Hospital.

出版信息

J Med Microbiol. 1987 Sep;24(2):175-80. doi: 10.1099/00222615-24-2-175.

DOI:10.1099/00222615-24-2-175

PMID:3309325

Abstract

A strain of Proteus mirabilis associated with chronic urinary tract infection was found to produce an EDTA-sensitive IgA protease that cleaved the IgA heavy chain into two fragments at sites different from those attacked by other microbial IgA1 proteases. Another 14 P. mirabilis strains of diverse type and from various clinical conditions also produced a similar IgA protease. This enzyme may be a virulence determinant of P. mirabilis.

摘要

一株与慢性尿路感染相关的奇异变形杆菌被发现可产生一种对乙二胺四乙酸（EDTA）敏感的IgA蛋白酶，该酶可在与其他微生物IgA1蛋白酶攻击位点不同的位置将IgA重链切割成两个片段。另外14株来自不同类型和各种临床病症的奇异变形杆菌菌株也产生了类似的IgA蛋白酶。这种酶可能是奇异变形杆菌的一种毒力决定因素。