老年社区获得性肺炎患者使用 5 天疗程的抗生素是否能达到既定的临床稳定标准？
Does a 5-day course of antibiotics in elderly patients with community-acquired pneumonia achieve the established criteria of clinical stability?
机构信息
Service des maladies infectieuses, Santépôle, groupe hospitalier sud Île-de-France, 270, avenue Marc-Jacquet, 77000 Melun, France.
Service de gériatrie, Santépôle, groupe hospitalier sud Île-de-France, 270, avenue Marc-Jacquet, 77000 Melun, France.
出版信息
Infect Dis Now. 2021 Jun;51(4):377-379. doi: 10.1016/j.medmal.2020.10.015. Epub 2020 Oct 20.
OBJECTIVE
We aimed to determine the proportion of elderly patients hospitalised for community-acquired pneumonia (CAP) in whom a 5-day antibiotic therapy would achieve clinical stability according to American Thoracic Society (ATS) criteria.
METHODS
Patients aged≥75 years, hospitalised for CAP between November 2018 and August 2019, were analysed retrospectively. The American Thoracic Society (ATS) clinical stability criteria (temperature≤37°C, heart rate≤100/min, respiratory rate≤24/min, systolic blood pressure≥90mmHg, oxygen saturation≥90% in room air) were assessed after five days of antibiotic therapy.
RESULTS
Seventy-five patients (mean age 88 years, 49% requiring oxygen therapy) were included. Six died, and at day 5, 36/69 (52%) fulfilled 4/5 stability criteria. The median duration of treatment was 9 days. In 28 patients (41%), it was ≤7 days.
CONCLUSION
In 52% of elderly patients with CAP, a 5-day treatment regimen resulted in clinical stability.
目的
我们旨在确定根据美国胸科学会（ATS）标准，因社区获得性肺炎（CAP）住院的老年患者中，5 天抗生素治疗可达到临床稳定的比例。
方法
回顾性分析了 2018 年 11 月至 2019 年 8 月因 CAP 住院的年龄≥75 岁的患者。在接受 5 天抗生素治疗后，评估美国胸科学会（ATS）的临床稳定标准（体温≤37°C、心率≤100/min、呼吸频率≤24/min、收缩压≥90mmHg、在室内空气下血氧饱和度≥90%）。
结果
共纳入 75 例患者（平均年龄 88 岁，49%需要氧疗）。6 例患者死亡，在第 5 天，69 例中有 36 例（52%）符合 4/5 项稳定性标准。中位治疗时间为 9 天。在 28 例患者（41%）中，治疗时间≤7 天。
结论
在 52%的 CAP 老年患者中，5 天的治疗方案可达到临床稳定。
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