糖尿病肾病患者中RAB38与尿蛋白肌酐比值（UPCR）水平的基因关联中的性别差异
Gender Differences in Genetic Associations of RAB38 with Urinary Protein-to-Creatinine Ratio (UPCR) Levels in Diabetic Nephropathy Patients.
作者信息
Yu Zhi-Lei, Wong Chung-Shun, Lai Yi Ting, Chou Wan-Hsuan, Faridah Imaniar Noor, Kao Chih-Chin, Lin Yuh-Feng, Chang Wei-Chiao
机构信息
Department of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei 110301, Taiwan.
Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 110301, Taiwan.
出版信息
J Pers Med. 2020 Oct 21;10(4):184. doi: 10.3390/jpm10040184.
Renal dysfunction is common in patients with diabetes mellitus (DM). Previous findings from a meta-analysis of GWAS indicated that the variation of is highly associated with the urinary albumin-to-creatinine ratio (UACR) in European populations. In addition, knockout rats showed an increase in urinary albumins. Although the prevalence of chronic kidney disease is high in Taiwan, the role of genetic variants in diabetic renal function is still unclear. In the current study, 275 diabetic nephropathy (DN) patients were recruited to perform a genetic association study. Our results indicated that rs1027027, rs302647, and rs302646 in were significantly associated with urinary protein-to-creatinine ratio (UPCR) levels in DN patients. Importantly, after analysis stratified by gender, a significant genetic influence on UPCR levels was observed in the male population. The findings confirmed the roles of gender and variants of in the risk of UPCR in Diabetic Nephropathy patients.
肾功能障碍在糖尿病患者中很常见。先前一项全基因组关联研究（GWAS）的荟萃分析结果表明，在欧洲人群中，[基因名称]的变异与尿白蛋白与肌酐比值（UACR）高度相关。此外，[基因名称]敲除大鼠的尿白蛋白增加。尽管台湾慢性肾脏病的患病率很高，但基因变异在糖尿病肾功能中的作用仍不清楚。在本研究中，招募了275例糖尿病肾病（DN）患者进行基因关联研究。我们的结果表明，[基因名称]中的rs1027027、rs302647和rs302646与DN患者的尿蛋白与肌酐比值（UPCR）水平显著相关。重要的是，在按性别分层分析后，在男性人群中观察到UPCR水平存在显著的基因影响。这些发现证实了性别和[基因名称]变异在糖尿病肾病患者UPCR风险中的作用。
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