Kosovskiĭ M I, Turakulov Ia Kh, Mirakhmedov M M, Katkova S P
Probl Endokrinol (Mosk). 1987 May-Jun;33(3):46-9.
Insulin insufficiency in rats caused by alloxan, results in a decrease in the sensitivity of the fatty tissue to insulin determined by glucose oxidation and synthesis of lipids manifested in a decrease in a maximum response of the tissue to insulin. Multiple injection of insulin as well as of partially purified total fraction of insulinoid growth factors causes an increase in a maximum response of the fatty tissue to insulin and a right-hand shift of dose-response curves. The total effect of the injection of insulin or partially purified growth factors is expressed in elevated sensitivity of the fatty tissue to insulin.
四氧嘧啶所致大鼠胰岛素不足，会导致脂肪组织对胰岛素的敏感性降低，这种敏感性由葡萄糖氧化及脂质合成决定，表现为该组织对胰岛素的最大反应降低。多次注射胰岛素以及部分纯化的胰岛素样生长因子总组分，会使脂肪组织对胰岛素的最大反应增加，且剂量-反应曲线右移。注射胰岛素或部分纯化的生长因子的总体效应表现为脂肪组织对胰岛素的敏感性升高。
