Gao He-Li, Wang Wen-Quan, Yu Xian-Jun, Liu Liang
Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, 270 Dong An Road, Shanghai, 20032 People's Republic of China.
Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong An Road, Shanghai, 200032 People's Republic of China.
Exp Hematol Oncol. 2020 Oct 22;9:28. doi: 10.1186/s40164-020-00184-0. eCollection 2020.
Pancreatic cancer is one of the most common causes of cancer-related deaths worldwide. The two major histological subtypes of pancreatic cancer are pancreatic ductal adenocarcinoma (PDAC), accounting for 90% of all cases, and pancreatic neuroendocrine neoplasm (PanNEN), which makes up 3-5% of all cases. PanNEN is classified into well-differentiated pancreatic neuroendocrine tumor and poorly-differentiated pancreatic neuroendocrine carcinoma (PanNEC). Although PDAC and PanNEN are commonly thought to be different diseases with distinct biology, cell of origin, and genomic abnormalities, the idea that PDAC and PanNEC share common cells of origin has been gaining support. This is substantiated by evidence that the molecular profiling of PanNEC is genetically and phenotypically related to PDAC. In the current review, we summarize published studies pointing to common potential cells of origin and speculate about how the distinct paths of differentiation are determined by the genomic patterns of each disease. We also discuss the overlap between PDAC and PanNEC, which has been noted in clinical observations.
胰腺癌是全球癌症相关死亡的最常见原因之一。胰腺癌的两种主要组织学亚型是胰腺导管腺癌（PDAC），占所有病例的90%，以及胰腺神经内分泌肿瘤（PanNEN），占所有病例的3 - 5%。PanNEN分为高分化胰腺神经内分泌肿瘤和低分化胰腺神经内分泌癌（PanNEC）。尽管通常认为PDAC和PanNEN是具有不同生物学特性、细胞起源和基因组异常的不同疾病，但PDAC和PanNEC具有共同细胞起源的观点已获得越来越多的支持。这一观点得到了证据的证实，即PanNEC的分子图谱在遗传和表型上与PDAC相关。在本综述中，我们总结了已发表的指向共同潜在细胞起源的研究，并推测每种疾病的基因组模式是如何决定不同的分化途径的。我们还讨论了在临床观察中已注意到的PDAC和PanNEC之间的重叠。
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