Copenhagen Prostate Cancer Center, Department of Urology, Copenhagen University Hospital, Rigshospitalet, Denmark.
Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen, Denmark.
Acta Oncol. 2021 Mar;60(3):316-322. doi: 10.1080/0284186X.2020.1837391. Epub 2020 Oct 24.
Vitamin D has a role in bone turnover and potentially bone-metastatic spread of prostate cancer (PCa). The aim of this observational study was to address the association between levels of serum vitamin D, diagnosis of PCa and subsequent mortality in men who underwent a biopsy of the prostate.
All men who underwent prostatic biopsy in the Danish PCa Registry (DaPCaR) and who had a serum vitamin D measurement during the period 2004 to 2010 ( = 4,065) were identified. Men were categorized by clinical cut-offs based on seasonally adjusted serum vitamin D levels in <25 (deficient), 25-50 (insufficient), 50-75 (sufficient) and >75 nmol/L (high) serum vitamin D. Logistic regression model for association between vitamin D and risk of PCa diagnosis and multivariate survival analyses were applied.
No association between serum vitamin D and risk of PCa was found. Overall survival was lowest for serum vitamin D deficiency and a significantly higher PCa specific mortality (HR: 2.37, 95%CI: 1.45-3.90, < .001) and other cause mortality (HR: 2.08, 95%CI: 1.33-3.24, = .001) was found for PCa patients with serum vitamin D deficiency compared to serum vitamin D sufficiency.
No association was found between serum vitamin D categories and risk of PCa in men who underwent biopsy of the prostate. Men with PCa and serum vitamin D deficiency had a higher overall and PCa specific mortality compared to men with a sufficient level of serum vitamin D.
维生素 D 在骨转换和前列腺癌（PCa）的骨转移扩散中具有作用。本观察性研究的目的是探讨血清维生素 D 水平与接受前列腺活检的男性 PCa 诊断和随后死亡率之间的关系。
确定了在丹麦前列腺癌登记处（DaPCaR）接受前列腺活检且在 2004 年至 2010 年期间进行血清维生素 D 测量的所有男性（ = 4065）。根据血清维生素 D 季节性调整水平，将男性分为以下临床切点：<25（缺乏）、25-50（不足）、50-75（充足）和>75 nmol/L（高）血清维生素 D。应用逻辑回归模型来分析维生素 D 与 PCa 诊断风险之间的关系，并进行多变量生存分析。
未发现血清维生素 D 与 PCa 风险之间存在关联。血清维生素 D 缺乏症患者的总体生存率最低，且 PCa 特异性死亡率（HR：2.37，95%CI：1.45-3.90， < .001）和其他原因死亡率（HR：2.08，95%CI：1.33-3.24， = .001）明显更高，与血清维生素 D 充足的 PCa 患者相比。
在接受前列腺活检的男性中，血清维生素 D 类别与 PCa 风险之间未发现关联。与血清维生素 D 充足的男性相比，患有 PCa 和血清维生素 D 缺乏症的男性的总体生存率和 PCa 特异性死亡率更高。
