Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain.
UGC de Reumatología, Hospital Regional Universitario de Málaga, Málaga, Spain.
Int J Rheum Dis. 2021 Jan;24(1):81-89. doi: 10.1111/1756-185X.14009. Epub 2020 Oct 28.
To evaluate cognitive function in adult patients with juvenile idiopathic arthritis (JIA) and associated factors.
We performed a cross-sectional observational study of adult patients with JIA and a healthy control group (no inflammatory diseases) matched for age, gender, and educational level. Cognitive function was assessed using Wechsler Adult Intelligence Scale-III. The cognitive domains measured were attention/concentration, verbal function, visuospatial organization, working memory, and problem solving (Similarities). Other measures included clinical-epidemiological characteristics, comorbid conditions, and treatment. We performed a descriptive bivariate analysis and logistic regression to identify factors associated with visuospatial involvement.
The study population comprised 104 subjects (52 with JIA and 52 healthy controls). Patients with JIA had poorer results for visuospatial function, with a lower median scaled score on the Block Design test (5.0 [4.0-8.0] vs 8.0 [5.0-10.0]; P = .014). The number of patients with scaled scores below the average range (<8) in visuospatial organization was significantly greater in the JIA group (67.3% vs 40.4%; P = .006). The multivariate analysis revealed time since diagnosis (odds ratio [95% CI], 1.03 [1.01-1.06]), inflammatory activity according to Juvenile Arthritis Disease Activity Score 27-joint count (1.94 [1.01-3.75]), and educational level (0.28 [0.08-0.94]) to be factors associated with visuospatial function.
Cognitive function in adult patients with JIA is poorer than in healthy controls at the expense of visuospatial function. Visuospatial function in JIA patients was inversely associated with disease duration, inflammatory activity, and lower educational level.
评估幼年特发性关节炎（JIA）成年患者的认知功能及其相关因素。
我们进行了一项横断面观察性研究，纳入了成年 JIA 患者和健康对照组（无炎症性疾病），两组按年龄、性别和教育程度相匹配。认知功能采用韦氏成人智力量表-III 进行评估。所测量的认知域包括注意力/集中力、语言功能、视空间组织、工作记忆和解决问题（相似性）。其他措施包括临床流行病学特征、合并症和治疗情况。我们进行了描述性双变量分析和逻辑回归，以确定与视空间受累相关的因素。
研究人群包括 104 名受试者（52 名 JIA 患者和 52 名健康对照者）。JIA 患者的视空间功能较差，其方块设计测验的中位数评分较低（5.0[4.0-8.0] vs 8.0[5.0-10.0]；P=0.014）。在视空间组织方面，JIA 组得分低于平均范围（<8）的患者比例明显更高（67.3% vs 40.4%；P=0.006）。多变量分析显示，诊断后时间（优势比[95%可信区间]，1.03[1.01-1.06]）、根据 27 关节计数的幼年特发性关节炎疾病活动评分（1.94[1.01-3.75]）和教育程度（0.28[0.08-0.94]）是与视空间功能相关的因素。
JIA 成年患者的认知功能较健康对照组差，视空间功能受损。JIA 患者的视空间功能与疾病持续时间、炎症活动度和较低的教育程度呈负相关。
