药物在胶束药物传递系统中的包载。

Drug Incorporation in the Drug Delivery System of Micelles.

机构信息

National Kapodistrian University of Athens, Panepistimiopolis, Zografou, Greece.

Laboratory for Molecular Structural Dynamics, National Institute of Chemistry, Ljubljana, Slovenia.

出版信息

Methods Mol Biol. 2021;2207:99-108. doi: 10.1007/978-1-0716-0920-0_8.

DOI:10.1007/978-1-0716-0920-0_8

PMID:33113130

Abstract

Micelles is a system frequently used for drug delivery. Drugs are incorporated and protected in micelles before being delivered. Nuclear magnetic resonance is a suitable technique to detect the localization and incorporation of drugs into the micelle system. Free radicals are used to further facilitate the probing of the interactions between drug and micelles. This information is critical because drug-micelle interactions determine how easily the drug will be released from micelles and therefore how easily will be delivered to the target.

摘要

胶束是一种常用于药物传递的系统。药物在递送至体内前被包裹在胶束中并受到保护。核磁共振是一种合适的技术，可用于检测药物在胶束系统中的定位和包裹情况。自由基则被用来进一步促进药物与胶束之间相互作用的探测。这些信息至关重要，因为药物与胶束之间的相互作用决定了药物从胶束中释放的难易程度，进而决定了药物递送至靶标的难易程度。