通过化学蛋白质组学发现免疫代谢中的翻译后修饰。
Discovery of post-translational modifications in immunometabolism by chemical proteomics.
机构信息
Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education,Peking University, Beijing 100871, China; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China.
Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education,Peking University, Beijing 100871, China; College of Chemistry and Molecular Engineering,Peking University, Beijing 100871, China; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China.
出版信息
Curr Opin Biotechnol. 2021 Apr;68:37-43. doi: 10.1016/j.copbio.2020.09.013. Epub 2020 Oct 24.
Metabolic reprogramming of macrophages during immune activation can generate diversified types of small molecule metabolites, which in turn induce post-translational modifications (PTMs) on proteins. Understanding the functional implications of these modifications requires precise identification of them from complex biological samples. We herein review recent progress in systematic discovery of immunometabolite PTMs by chemical proteomics.
在免疫激活过程中，巨噬细胞的代谢重编程可以产生多样化的小分子代谢物，进而诱导蛋白质的翻译后修饰（PTMs）。为了理解这些修饰的功能意义，需要从复杂的生物样本中精确地鉴定它们。本文综述了化学蛋白质组学系统发现免疫代谢物 PTM 的最新进展。
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