Genovese Giovanni, Derlino Federica, Berti Emilio, Marzano Angelo Valerio
Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy.
Front Pharmacol. 2020 Oct 2;11:583354. doi: 10.3389/fphar.2020.583354. eCollection 2020.
Pregnancy may induce the onset or exacerbation of autoimmune bullous diseases such as pemphigus or pemphigoid gestationis. A shift toward T helper (Th) 2 immune response and the influence of hormonal changes have been evoked as possible triggering factors. Therapeutic management of this setting of patients may represent a challenge, mainly due to safety concerns of some immunosuppressive drugs during pregnancy and lactation. In this narrative review, we provided a comprehensive overview of the therapeutic management of autoimmune bullous diseases in pregnant and breastfeeding women, focusing on pemphigus and pemphigoid gestationis.
妊娠可能诱发自身免疫性大疱性疾病的发作或加重，如天疱疮或妊娠类天疱疮。向辅助性T细胞（Th）2免疫反应的转变以及激素变化的影响被认为是可能的触发因素。这类患者的治疗管理可能是一项挑战，主要是因为某些免疫抑制药物在妊娠和哺乳期的安全性问题。在这篇叙述性综述中，我们全面概述了妊娠和哺乳期妇女自身免疫性大疱性疾病的治疗管理，重点关注天疱疮和妊娠类天疱疮。
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