靶向Orai1介导的心力衰竭中的钙库操纵性钙内流
Targeting Orai1-Mediated Store-Operated Ca Entry in Heart Failure.
作者信息
Luo Rui, Gomez Ana-Maria, Benitah Jean-Pierre, Sabourin Jessica
机构信息
Inserm, UMR-S 1180, Signalisation et Physiopathologie Cardiovasculaire, Université Paris-Saclay, Châtenay-Malabry, France.
出版信息
Front Cell Dev Biol. 2020 Oct 8;8:586109. doi: 10.3389/fcell.2020.586109. eCollection 2020.
Abstract
The archetypal store-operated Ca channels (SOCs), Orai1, which are stimulated by the endo/sarcoplasmic reticulum (ER/SR) Ca sensor stromal interaction molecule 1 (STIM1) upon Ca store depletion is traditionally viewed as instrumental for the function of non-excitable cells. In the recent years, expression and function of Orai1 have gained recognition in excitable cardiomyocytes, albeit controversial. Even if its cardiac physiological role in adult is still elusive and needs to be clarified, Orai1 contribution in cardiac diseases such as cardiac hypertrophy and heart failure (HF) is increasingly recognized. The present review surveys our current arising knowledge on the new role of Orai1 channels in the heart and debates on its participation to cardiac hypertrophy and HF.
摘要
典型的储存操纵性钙通道（SOCs），即Orai1，在钙储存耗竭时由内质网/肌浆网（ER/SR）钙传感器基质相互作用分子1（STIM1）刺激，传统上被认为对非兴奋性细胞的功能至关重要。近年来，Orai1在可兴奋的心肌细胞中的表达和功能已得到认可，尽管存在争议。即使其在成人心脏生理中的作用仍不明确且有待阐明，但Orai1在诸如心肌肥大和心力衰竭（HF）等心脏疾病中的作用越来越受到认可。本综述概述了我们目前对Orai1通道在心脏中的新作用的认识，并对其参与心肌肥大和HF进行了讨论。
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