Reproductive Medicine Center, Nanning Maternal and Child Health Care Hospital, Nanning, China.
College of Biotechnology, Guilin Medical University, Guilin, Guangxi, China.
J Int Med Res. 2020 Oct;48(10):300060520966538. doi: 10.1177/0300060520966538.
The purpose of this study was to investigate the effect of gonadotropin dose and endometrial thickness (EMT) on pregnancy outcome in patients undergoing intrauterine insemination (IUI).
We retrospectively analyzed data from 361 patients with unexplained infertility or polycystic ovarian syndrome (PCOS) who underwent 930 IUI cycles treated with gonadotropins. Then, we measured the effects of gonadotropins and EMT on the clinical pregnancy rate. Finally, we assessed the association of various doses of gonadotropins on EMT.
The dose of gonadotropins given and thickness of the endometrium were higher in the pregnancy group than in the nonpregnancy group (636.0 vs. 600.0 IU for gonadotropin dose; 9.15 vs. 8.70 mm for EMT). Clinical pregnancy rates were significantly improved by increasing the dose of gonadotropins (9.1%, <450 IU; 16.2%, 450-599 IU; 18.6%, 600-749 IU, and 17.3%, ≥750 IU), or by increased EMT (0%, <5.0 mm; 12.2%, 5.0-6.9 mm; 15.5%, 7.0-14.0 mm; and 33.3%, >14.0 mm).
Increasing the dose of gonadotropins to stimulate one follicle to develop may benefit endometrial proliferation and improve IUI outcomes.
本研究旨在探讨促性腺激素剂量和子宫内膜厚度（EMT）对宫腔内人工授精（IUI）患者妊娠结局的影响。
我们回顾性分析了 361 例不明原因不孕或多囊卵巢综合征（PCOS）患者的资料，这些患者接受了促性腺激素治疗的 930 个 IUI 周期。然后，我们测量了促性腺激素和 EMT 对临床妊娠率的影响。最后，我们评估了各种剂量的促性腺激素对 EMT 的影响。
妊娠组的促性腺激素用量和子宫内膜厚度均高于非妊娠组（促性腺激素剂量 636.0 vs. 600.0IU；EMT 9.15 vs. 8.70mm）。随着促性腺激素剂量的增加（9.1%，<450IU；16.2%，450-599IU；18.6%，600-749IU；17.3%，≥750IU），或 EMT 增加（0%，<5.0mm；12.2%，5.0-6.9mm；15.5%，7.0-14.0mm；33.3%，>14.0mm），临床妊娠率显著提高。
增加促性腺激素剂量以刺激一个卵泡发育可能有益于子宫内膜增殖，提高 IUI 结局。
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