• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

转化生长因子-β1诱导的MALAT1上调通过上皮-间质转化促进哈萨克族食管鳞状细胞癌侵袭。

TGF-β1-Induced Upregulation of MALAT1 Promotes Kazakh's Esophageal Squamous Cell Carcinoma Invasion by EMT.

作者信息

Liu Qing, Zheng Shutao, Chen Yumei, Liu Tao, Han Xiujuan, Zhang Xiao, Shen Tongxue, Lu Xiaomei

机构信息

Clinical Medical Research Institute, First Affiliated Hospital of Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Urumqi, PR China.

State Key Laboratory of Pathogenesis, Prevention, Treatment of High Incidence Diseases in Central Asian, Xinjiang Uygur Autonomous Region, Urumqi, PR China.

出版信息

J Cancer. 2020 Oct 4;11(23):6892-6901. doi: 10.7150/jca.48426. eCollection 2020.

DOI:10.7150/jca.48426
PMID:33123280
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7592017/
Abstract

Transforming growth factor β1 (TGF-β1) plays an important role in tumor initiation and development by inducing epithelial-mesenchymal Transition (EMT). Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) is a long noncoding RNA (lncRNA) that contributes to the invasion and metastasis of tumors, including esophageal squamous cell carcinoma (ESCC). The aim of the present study was to explore the underlying mechanisms implicated in EMT and to clarify whether TGF-β1 regulates MALAT1 expression, thereby promoting the invasion of ESCC. Expression of TGF-β1, MALAT1 and EMT-related markers, including E-cadherin and Vimentin, was detected in clinical samples of Kazakh's ESCC. The role of TGF-β1 in the regulation of MALAT1 in ESCC invasion was evaluated at the ESCC cell line level. High TGF-β1 expression was significantly associated with poor survival among patients with Kazakh's ESCC. Additionally, the expression of Vimentin was upregulated, and the expression of E-cadherin was downregulated and varied. The expression of MALAT1 positively correlated with the expression of TGF-β1 both and . Furthermore, knockdown of MALAT1 inhibited TGF-β1-induced EMT. Our data indicate that MALAT1 is heavily involved in EMT induced by TGF-β1. MALAT1 may be a therapeutic target in the suppression of metastasis and invasion of ESCC.

摘要

转化生长因子β1（TGF-β1）通过诱导上皮-间质转化（EMT）在肿瘤的起始和发展中发挥重要作用。转移相关的肺腺癌转录本1（MALAT1）是一种长链非编码RNA（lncRNA），它促进包括食管鳞状细胞癌（ESCC）在内的肿瘤的侵袭和转移。本研究的目的是探讨EMT的潜在机制，并阐明TGF-β1是否调节MALAT1的表达，从而促进ESCC的侵袭。在哈萨克族ESCC临床样本中检测TGF-β1、MALAT1以及EMT相关标志物（包括E-钙黏蛋白和波形蛋白）的表达。在ESCC细胞系水平评估TGF-β1在调节MALAT1对ESCC侵袭中的作用。哈萨克族ESCC患者中TGF-β1高表达与较差的生存率显著相关。此外，波形蛋白表达上调，E-钙黏蛋白表达下调且存在差异。MALAT1的表达与TGF-β1的表达在[此处原文缺失具体相关内容]均呈正相关。此外，敲低MALAT1可抑制TGF-β1诱导的EMT。我们的数据表明，MALAT1在很大程度上参与了TGF-β1诱导的EMT。MALAT1可能是抑制ESCC转移和侵袭的治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e444/7592017/714e25a58eec/jcav11p6892g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e444/7592017/05cdb09f64b5/jcav11p6892g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e444/7592017/e966902977be/jcav11p6892g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e444/7592017/75fa56b659ef/jcav11p6892g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e444/7592017/933094b8bb58/jcav11p6892g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e444/7592017/34a00cfd9c4b/jcav11p6892g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e444/7592017/c661cfb02d05/jcav11p6892g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e444/7592017/714e25a58eec/jcav11p6892g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e444/7592017/05cdb09f64b5/jcav11p6892g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e444/7592017/e966902977be/jcav11p6892g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e444/7592017/75fa56b659ef/jcav11p6892g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e444/7592017/933094b8bb58/jcav11p6892g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e444/7592017/34a00cfd9c4b/jcav11p6892g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e444/7592017/c661cfb02d05/jcav11p6892g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e444/7592017/714e25a58eec/jcav11p6892g007.jpg

相似文献

1
TGF-β1-Induced Upregulation of MALAT1 Promotes Kazakh's Esophageal Squamous Cell Carcinoma Invasion by EMT.转化生长因子-β1诱导的MALAT1上调通过上皮-间质转化促进哈萨克族食管鳞状细胞癌侵袭。
J Cancer. 2020 Oct 4;11(23):6892-6901. doi: 10.7150/jca.48426. eCollection 2020.
2
TGF-β1/Smad signaling pathway regulates epithelial-to-mesenchymal transition in esophageal squamous cell carcinoma: in vitro and clinical analyses of cell lines and nomadic Kazakh patients from northwest Xinjiang, China.转化生长因子-β1/信号转导和转录激活因子信号通路调控食管鳞状细胞癌的上皮-间质转化：对中国新疆西北部哈萨克族游牧民患者的细胞系及临床分析
PLoS One. 2014 Dec 2;9(12):e112300. doi: 10.1371/journal.pone.0112300. eCollection 2014.
3
CDCA7 promotes TGF-β-induced epithelial-mesenchymal transition via transcriptionally regulating Smad4/Smad7 in ESCC.CDCA7 通过转录调控 ESCC 中的 Smad4/Smad7 促进 TGF-β诱导的上皮-间充质转化。
Cancer Sci. 2023 Jan;114(1):91-104. doi: 10.1111/cas.15560. Epub 2022 Nov 14.
4
Role of matrix metalloproteinase-9 in transforming growth factor-β1-induced epithelial-mesenchymal transition in esophageal squamous cell carcinoma.基质金属蛋白酶-9在转化生长因子-β1诱导的食管鳞状细胞癌上皮-间质转化中的作用
Onco Targets Ther. 2017 Jun 2;10:2837-2847. doi: 10.2147/OTT.S134813. eCollection 2017.
5
Transforming growth factor-β1-induced epithelial-mesenchymal transition in human esophageal squamous cell carcinoma via the PTEN/PI3K signaling pathway.转化生长因子-β1通过PTEN/PI3K信号通路诱导人食管鳞状细胞癌发生上皮-间质转化
Oncol Rep. 2014 Nov;32(5):2134-42. doi: 10.3892/or.2014.3453. Epub 2014 Aug 29.
6
Erratum: TGF-β1-Induced Upregulation of MALAT1 Promotes Kazakh's Esophageal Squamous Cell Carcinoma Invasion by EMT: Erratum.勘误：转化生长因子-β1诱导的MALAT1上调通过上皮-间质转化促进哈萨克族食管鳞状细胞癌侵袭：勘误
J Cancer. 2022 Apr 25;13(8):2414. doi: 10.7150/jca.73596. eCollection 2022.
7
PKM2-regulated STAT3 promotes esophageal squamous cell carcinoma progression via TGF-β1-induced EMT.丙酮酸激酶M2（PKM2）调控的信号转导和转录激活因子3（STAT3）通过转化生长因子-β1（TGF-β1）诱导的上皮-间质转化促进食管鳞状细胞癌进展。
J Cell Biochem. 2019 Jul;120(7):11539-11550. doi: 10.1002/jcb.28434. Epub 2019 Feb 12.
8
TGF-β-induced upregulation of malat1 promotes bladder cancer metastasis by associating with suz12.TGF-β 诱导的 malat1 上调通过与 suz12 结合促进膀胱癌转移。
Clin Cancer Res. 2014 Mar 15;20(6):1531-41. doi: 10.1158/1078-0432.CCR-13-1455. Epub 2014 Jan 21.
9
M2 isoform of pyruvate kinase (PKM2) is upregulated in Kazakh's ESCC and promotes proliferation and migration of ESCC cells.丙酮酸激酶M2亚型（PKM2）在哈萨克族食管癌组织中表达上调，促进食管癌细胞的增殖和迁移。
Tumour Biol. 2016 Feb;37(2):2665-72. doi: 10.1007/s13277-015-4073-z. Epub 2015 Sep 24.
10
MiR-106b promotes migration and invasion through enhancing EMT via downregulation of Smad 7 in Kazakh's esophageal squamous cell carcinoma.在哈萨克族食管鳞状细胞癌中，miR-106b通过下调Smad 7增强上皮-间质转化（EMT），从而促进细胞迁移和侵袭。
Tumour Biol. 2016 Nov;37(11):14595-14604. doi: 10.1007/s13277-016-5338-x. Epub 2016 Sep 12.

引用本文的文献

1
Development and validation of a high-throughput screening pipeline of compound libraries to target EMT.用于靶向上皮-间质转化的化合物库高通量筛选流程的开发与验证
Cell Death Differ. 2025 May 8. doi: 10.1038/s41418-025-01515-6.
2
MALAT-1 Is a Key Regulator of Epithelial-Mesenchymal Transition in Cancer: A Potential Therapeutic Target for Metastasis.MALAT-1是癌症上皮-间质转化的关键调节因子：一种潜在的转移治疗靶点。
Cancers (Basel). 2024 Jan 4;16(1):234. doi: 10.3390/cancers16010234.
3
RNF6 activates TGF-β1/c-Myb pathway to promote EMT in esophageal squamous cell carcinoma.

本文引用的文献

1
The long-noncoding RNA MALAT1 regulates TGF-β/Smad signaling through formation of a lncRNA-protein complex with Smads, SETD2 and PPM1A in hepatic cells.长链非编码 RNA MALAT1 通过与 Smads、SETD2 和 PPM1A 形成 lncRNA-蛋白复合物来调节 TGF-β/Smad 信号通路在肝细胞中的作用。
PLoS One. 2020 Jan 29;15(1):e0228160. doi: 10.1371/journal.pone.0228160. eCollection 2020.
2
Long noncoding RNA MALAT1 as a candidate serological biomarker for the diagnosis of non-small cell lung cancer: A meta-analysis.长链非编码 RNA MALAT1 作为非小细胞肺癌血清学诊断标志物的候选物：一项荟萃分析。
Thorac Cancer. 2020 Feb;11(2):329-335. doi: 10.1111/1759-7714.13265. Epub 2019 Dec 17.
3
RNF6激活TGF-β1/c-Myb信号通路以促进食管鳞状细胞癌的上皮-间质转化。
Front Oncol. 2023 Feb 9;13:1081333. doi: 10.3389/fonc.2023.1081333. eCollection 2023.
4
Epigenetic regulation of cutaneous T-cell lymphoma is mediated by dysregulated lncRNA MALAT1 through modulation of tumor microenvironment.皮肤T细胞淋巴瘤的表观遗传调控是由失调的长链非编码RNA MALAT1通过调节肿瘤微环境介导的。
Front Oncol. 2022 Aug 17;12:977266. doi: 10.3389/fonc.2022.977266. eCollection 2022.
5
Erratum: TGF-β1-Induced Upregulation of MALAT1 Promotes Kazakh's Esophageal Squamous Cell Carcinoma Invasion by EMT: Erratum.勘误：转化生长因子-β1诱导的MALAT1上调通过上皮-间质转化促进哈萨克族食管鳞状细胞癌侵袭：勘误
J Cancer. 2022 Apr 25;13(8):2414. doi: 10.7150/jca.73596. eCollection 2022.
6
Cytokine Interaction With Cancer-Associated Fibroblasts in Esophageal Cancer.细胞因子与食管癌相关成纤维细胞的相互作用。
Cancer Control. 2022 Jan-Dec;29:10732748221078470. doi: 10.1177/10732748221078470.
7
Epiplakin1 promotes the progression of esophageal squamous cell carcinoma by activating the PI3K-AKT signaling pathway.Epiplakin1 通过激活 PI3K-AKT 信号通路促进食管鳞状细胞癌的进展。
Thorac Cancer. 2022 Apr;13(8):1117-1125. doi: 10.1111/1759-7714.14366. Epub 2022 Mar 3.
8
Dexmedetomidine inhibits the growth and metastasis of esophageal cancer cells by down-regulation of lncRNA MALAT1.右美托咪定通过下调lncRNA MALAT1抑制食管癌细胞的生长和转移。
Kaohsiung J Med Sci. 2022 Jun;38(6):585-593. doi: 10.1002/kjm2.12506. Epub 2022 Feb 24.
9
The Multifaceted Role of TGF-β in Gastrointestinal Tumors.转化生长因子-β在胃肠道肿瘤中的多方面作用
Cancers (Basel). 2021 Aug 5;13(16):3960. doi: 10.3390/cancers13163960.
Cancer statistics: a comparison between World Health Organization (WHO) and Global Burden of Disease (GBD).
癌症统计数据：世界卫生组织（WHO）与全球疾病负担（GBD）之间的比较。
Eur J Public Health. 2020 Oct 1;30(5):1026-1027. doi: 10.1093/eurpub/ckz216.
4
Long non-coding RNA MALAT1 as a valuable biomarker for prognosis in osteosarcoma: A systematic review and meta-analysis.长链非编码 RNA MALAT1 作为骨肉瘤预后有价值的生物标志物：系统评价和荟萃分析。
Int J Surg. 2019 Dec;72:206-213. doi: 10.1016/j.ijsu.2019.11.004. Epub 2019 Nov 15.
5
Deciphering the Molecular Basis of Melatonin Protective Effects on Breast Cells Treated with Doxorubicin: TWIST1 a Transcription Factor Involved in EMT and Metastasis, a Novel Target of Melatonin.解析褪黑素对阿霉素处理的乳腺细胞保护作用的分子基础：TWIST1，一种参与上皮-间质转化和转移的转录因子，是褪黑素的新靶点。
Cancers (Basel). 2019 Jul 19;11(7):1011. doi: 10.3390/cancers11071011.
6
High Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) Expression Promotes Proliferation, Migration, and Invasion of Non-Small Cell Lung Cancer via ERK/Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway.高转移相关肺腺癌转录本 1（MALAT1）表达通过 ERK/丝裂原活化蛋白激酶（MAPK）信号通路促进非小细胞肺癌的增殖、迁移和侵袭。
Med Sci Monit. 2019 Jul 11;25:5143-5149. doi: 10.12659/MSM.913308.
7
Association of tumour-associated macrophages with cancer cell EMT, invasion, and metastasis of Kazakh oesophageal squamous cell cancer.肿瘤相关巨噬细胞与哈萨克族食管鳞癌 EMT、侵袭和转移的关系。
Diagn Pathol. 2019 Jun 12;14(1):55. doi: 10.1186/s13000-019-0834-0.
8
Cancer treatment and survivorship statistics, 2019.2019 年癌症治疗与生存统计
CA Cancer J Clin. 2019 Sep;69(5):363-385. doi: 10.3322/caac.21565. Epub 2019 Jun 11.
9
Long Noncoding RNA MALAT1 Acts as a Competing Endogenous RNA to Regulate TGF-2 Induced Epithelial-Mesenchymal Transition of Lens Epithelial Cells by a MicroRNA-26a-Dependent Mechanism.长链非编码 RNA MALAT1 通过 microRNA-26a 依赖的机制作为竞争内源性 RNA 调节 TGF-β2 诱导的晶状体上皮细胞上皮-间充质转化。
Biomed Res Int. 2019 Apr 22;2019:1569638. doi: 10.1155/2019/1569638. eCollection 2019.
10
LncRNA MALAT1 facilities high glucose induced endothelial to mesenchymal transition and fibrosis via targeting miR-145/ZEB2 axis.长链非编码 RNA MALAT1 通过靶向 miR-145/ZEB2 轴促进高糖诱导的内皮细胞向间充质细胞转化和纤维化。
Eur Rev Med Pharmacol Sci. 2019 Apr;23(8):3478-3486. doi: 10.26355/eurrev_201904_17713.