Unit of Respiratory Medicine, Department of Experimental Medicine, University of Rome "Tor Vergata", Via Montpellier 1, 00133, Rome, Italy.
Division of Respiratory Medicine, University Hospital "Policlinico Tor Vergata", Rome, Italy.
Respir Res. 2020 Oct 30;21(1):286. doi: 10.1186/s12931-020-01550-6.
It has been recently hypothesized that infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may lead to fibrotic sequelae in patients recovering from coronavirus disease 2019 (COVID-19). In this observational study, hospitalized patients with COVID-19 had a HRCT of the chest performed to detect the extension of fibrotic abnormalities via Hounsfield Units (HU). At follow-up, the lung density significantly improved in both lungs and in each lobe of all patients, being in the normal range (- 950 to - 700 HU). This study provides preliminary evidence that hospitalized patients with mild-to-moderate forms of COVID-19 are not at risk of developing pulmonary fibrosis.
最近有人假设，严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）感染可能导致 2019 冠状病毒病（COVID-19）康复患者出现纤维化后遗症。在这项观察性研究中，对 COVID-19 住院患者进行了胸部高分辨率计算机断层扫描（HRCT），通过亨氏单位（HU）检测纤维化异常的程度。随访时，所有患者的双肺和每个肺叶的肺密度均显著改善，均处于正常范围（-950 至-700 HU）。本研究初步表明，轻至中度 COVID-19 住院患者不会发生肺纤维化的风险。
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