Department of Physical Therapy, Faculty of Health and Welfare, Tokushima Bunri University, Tokushima, Tokushima, Japan.
Department of Rehabilitation, Kasei Tamura Hospital, Wakayama, Wakayama, Japan.
J Am Med Dir Assoc. 2021 Jun;22(6):1287-1291.e1. doi: 10.1016/j.jamda.2020.09.017. Epub 2020 Oct 27.
Although older inpatients are known to develop various conditions, whether aging affects intramuscular adipose tissue in older inpatients remains unclear. In particular, an increase in intramuscular adipose tissue in persons aged ≥85 years has previously not been revealed in either older inpatients or community-dwelling older individuals. This study therefore aimed to examine whether aging affects intramuscular adipose tissue in older inpatients.
Cross-sectional study.
This study was clinical-based and included 404 inpatients aged ≥65 years.
We divided the participants into the following age groups: 65-74 years (n = 63), 75-84 years (n = 171), and ≥85 years (n = 170). B-mode ultrasound imaging was performed, and the intramuscular adipose tissue of the quadriceps was assessed based on echo intensity. One-way analysis of variance and analysis of covariance were used to compare the echo intensity of the quadriceps between the 65-74-year, 75-84-year, and ≥85-year groups.
The median (25th-75th percentile) ages of the 65-74-year group, 75-84-year group, and ≥85-year group were 70.0 (68.0-73.0), 80.0 (77.0-82.0), and 89.0 (87.0-91.0), respectively. In the one-way analysis of variance, the quadriceps echo intensity of the ≥85-year group was significantly higher than that of the 65-74-year and 75-84-year groups. In addition, the ≥85-year group had significantly higher quadriceps echo intensity than the 65-74-year group, even after adjusting for other confounding factors.
The current study revealed that intramuscular adipose tissue in older inpatients increases with age, and the levels of intramuscular adipose tissue of older inpatients aged ≥85 years is higher than those of older inpatients aged 65-74 years.
尽管已知老年住院患者会出现各种病症，但年龄是否会影响老年住院患者的肌肉内脂肪组织尚不清楚。特别是，以前在老年住院患者或社区居住的老年人中均未发现 85 岁及以上人群的肌肉内脂肪组织增加。因此，本研究旨在探讨年龄是否会影响老年住院患者的肌肉内脂肪组织。
横断面研究。
本研究基于临床，纳入了 404 名年龄≥65 岁的住院患者。
我们将参与者分为以下年龄组：65-74 岁（n=63）、75-84 岁（n=171）和≥85 岁（n=170）。使用 B 型超声成像对股四头肌的肌肉内脂肪组织进行评估，并根据回声强度进行评估。采用单因素方差分析和协方差分析比较 65-74 岁、75-84 岁和≥85 岁组股四头肌的回声强度。
65-74 岁组、75-84 岁组和≥85 岁组的中位（25 分位至 75 分位）年龄分别为 70.0（68.0-73.0）、80.0（77.0-82.0）和 89.0（87.0-91.0）。在单因素方差分析中，≥85 岁组股四头肌回声强度明显高于 65-74 岁和 75-84 岁组。此外，即使在校正了其他混杂因素后，≥85 岁组的股四头肌回声强度也明显高于 65-74 岁组。
本研究表明，老年住院患者的肌肉内脂肪组织随年龄增长而增加，≥85 岁老年住院患者的肌肉内脂肪组织水平高于 65-74 岁老年住院患者。
