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通过吸入暴露于淋浴水中的三卤甲烷评估癌症风险。

Cancer risk assessment from exposure to trihalomethanes in showers by inhalation.

机构信息

Environmental Engineering Research Center. Department of Civil and Environmental Engineering, Universidad de Los Andes, Bogotá, Colombia.

Environmental Engineering Research Center. Department of Civil and Environmental Engineering, Universidad de Los Andes, Bogotá, Colombia.

出版信息

Environ Res. 2021 May;196:110401. doi: 10.1016/j.envres.2020.110401. Epub 2020 Oct 29.

Abstract

In many countries water disinfection for human consumption is still carried out via chlorination which generates by-products such as trihalomethanes (THM). Exposure to THM constitutes a public health risk as such substances are known to be carcinogenic. This study evaluated exposure to THMs by inhalation in showers and assessed the carcinogenic risk for lifetime exposure. The study population involved students at Universidad de los Andes residing in Bogotá, Colombia. The risk assessment was performed stochastically and the exposure parameters were taken as probability distributions. Most variables were measured in relation to the chosen population. The risk was calculated using two different methodologies but no significant variations were obtained. The average risk calculated for men and women was 56 cases in a million (5.6 × 10). A sensitivity analysis was carried out where it was found that the parameters that increase risk the most are the concentration of chloroform in the water, exposure time, and the volume of the shower cubicle.

摘要

在许多国家,饮用水的消毒仍通过氯化来进行,而这会产生三卤甲烷(THM)等副产物。接触 THM 会构成公共健康风险,因为这些物质已被证实具有致癌性。本研究通过吸入淋浴水中的 THM 来评估接触量,并评估终生接触的致癌风险。研究人群包括哥伦比亚波哥大的安第斯大学的学生。风险评估是通过随机进行的,暴露参数被视为概率分布。大多数变量是根据所选人群进行测量的。使用两种不同的方法计算了风险,但没有得到显著差异。为男性和女性计算的平均风险为每百万 56 例(5.6×10)。进行了敏感性分析,结果发现,增加风险的最重要参数是水中氯仿的浓度、暴露时间和淋浴间的体积。

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