Guangzhou Institute of Dermatology, Guangzhou, China.
Department of Epidemiology and Biostatistics, College for Public Health & Social Justice, Saint Louis University, St Louis, MO, USA.
Br J Dermatol. 2021 Jun;184(6):1068-1076. doi: 10.1111/bjd.19645. Epub 2021 Feb 1.
The short-term effect of ambient air pollution on atopic dermatitis (AD), along with its effect modifiers, has not been fully addressed.
To examine the short-term associations between air pollution and AD, and to identify effect modifications by age and season.
We used the generalized additive model to evaluate the short-term effect of ambient air pollution on daily hospital visits for AD, adjusting for potential confounders. Subgroup analyses were performed to identify potential effect modifications by season and age (< 18 years and ≥ 18 years).
A total of 29 972 hospital visits for AD were recorded in Guangzhou, China, from 19 January 2013 to 31 December 2017. Among them, 72·8% were visits by children and 51·4% occurred in the cool season. Acute and delayed effects on AD hospital visits were significant for all air pollutants. Stronger effects were seen in the cool season (approximately 1·7-3·0 times higher than effects in the warm season). Stronger effects were also observed in children (approximately 1·3-1·8 times higher than effects in adults). Sensitivity analyses indicated the results were robust.
Air pollution might be an important trigger for AD in subtropical Guangzhou, China. Children are more vulnerable than adults, and the effects are stronger in the cool season.
大气污染对特应性皮炎（AD）的短期影响及其影响因素尚未得到充分研究。
探讨大气污染与 AD 之间的短期关联，并确定年龄和季节的影响修饰作用。
我们使用广义相加模型来评估环境空气污染对 AD 每日住院的短期影响，同时调整了潜在的混杂因素。进行了亚组分析，以确定季节和年龄（<18 岁和≥18 岁）的潜在影响修饰作用。
在中国广州，从 2013 年 1 月 19 日至 2017 年 12 月 31 日，共记录了 29972 例 AD 住院就诊。其中，72.8%为儿童就诊，51.4%发生在凉爽季节。所有空气污染物对 AD 住院就诊均有明显的急性和延迟效应。在凉爽季节，影响更大（比温暖季节的影响高约 1.7-3.0 倍）。在儿童中也观察到更强的影响（比成年人高约 1.3-1.8 倍）。敏感性分析表明结果是稳健的。
在中国亚热带广州，空气污染可能是 AD 的一个重要诱发因素。儿童比成人更易受影响，在凉爽季节影响更强。
