免疫功能低下宿主的抗生素耐药性感染及治疗挑战：最新进展
Antibiotic-Resistant Infections and Treatment Challenges in the Immunocompromised Host: An Update.
作者信息
Dumford Donald, Skalweit Marion J
机构信息
Department of Medicine, Northeast Ohio Medical University, 4209 St. Rt. 44, PO Box 95, Rootstown, OH 44272, USA; Division of Infectious Diseases, Cleveland Clinic Akron General, 224 West Exchange Street, Suite 290, Akron, OH 44302, USA.
Case Western Reserve University School of Medicine, 2109 Adelbert Road, Cleveland, OH 44106, USA; Louis Stokes Cleveland Department of Veterans Affairs, 10701 East Boulevard 111 (W), Cleveland, OH 44106, USA.
出版信息
Infect Dis Clin North Am. 2020 Dec;34(4):821-847. doi: 10.1016/j.idc.2020.08.005.
This article reviews antibiotic resistance and treatment of bacterial infections in the growing number of patients who are immunocompromised: solid organ transplant recipients, the neutropenic host, and persons with human immunodeficiency virus and AIDS. Specific mechanisms of resistance in both gram-negative and gram-positive bacteria, as well as newer treatment options are addressed elsewhere and are only briefly discussed in the context of the immunocompromised host.
本文综述了在越来越多免疫功能低下患者（实体器官移植受者、中性粒细胞减少宿主以及人类免疫缺陷病毒感染者和艾滋病患者）中细菌感染的抗生素耐药性及治疗情况。革兰氏阴性菌和革兰氏阳性菌的具体耐药机制以及新的治疗选择在其他地方已有论述，本文仅在免疫功能低下宿主的背景下进行简要讨论。
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