Mandel Iván, Farkasdi Sándor, Varga Gábor, Nagy Ákos Károly
- University of Pécs, Medical School, Department of Dentistry, Oral and Maxillofacial Surgery, Pécs, Hungary.
- Semmelweis University, Faculty of Dentistry, Department of Oral Biology, Budapest, Hungary.
Acta Stomatol Croat. 2020 Sep;54(3):227-237. doi: 10.15644/asc54/3/1.
The aim was to investigate the efficacy of single injections of two different hyaluronic acid products, Flex Barrier and Revident, in reducing the size of black triangles to treat Nordland-Tarnow Class I and II recessions.
Forty adult patients were recruited with at least two upper and two lower interdental papilla defects in the front region between canine teeth. According to the Nordland-Tarnow classification of papillary defects, both Class I and Class II recessions were included in the investigation. Patients were randomly assigned to experimental groups to receive single injections of two different hyaluronic acid products, either Flex Barrier or Revident. The untreated sites served as controls. Photographs were taken before and immediately after the treatment, and again after one week and one month. To determine the size of the black triangles, Image J software was used. For statistical analysis, a mixed-design ANOVA was applied.
Both Flex Barrier and Revident significantly decreased the size of the treated defects immediately after the treatment and also one week later (p<0.001). The beneficial effect of Revident lasted longer than Flex Barrier as it remained significant even after one month in Revident-treated patients, however, not in the Flex Barrier-treated group. Furthermore, Nordland-Tarnow Class I lesions generally showed a greater improvement than Class II lesions.
In this proof-of-concept, randomized clinical trial we have demonstrated the clinical applicability of both Flex Barrier and Revident, although Revident gave longer-lasting improvements than Flex Barrier. Further trials are needed to optimize multiple-application protocols for treating gingival black triangles.
旨在研究单次注射两种不同透明质酸产品Flex Barrier和Revident在减小黑三角大小以治疗诺德兰-塔尔诺I类和II类牙龈退缩方面的疗效。
招募了40名成年患者，其犬齿前方区域至少有两个上颌和两个下颌牙间乳头缺损。根据诺德兰-塔尔诺乳头缺损分类，I类和II类退缩均纳入研究。患者被随机分配到实验组，接受单次注射两种不同的透明质酸产品，即Flex Barrier或Revident。未治疗的部位作为对照。在治疗前、治疗后即刻、一周后和一个月后拍照。使用Image J软件确定黑三角的大小。进行统计分析时，应用了混合设计方差分析。
Flex Barrier和Revident在治疗后即刻以及一周后均显著减小了治疗缺损的大小（p<0.001）。Revident的有益效果比Flex Barrier持续时间更长，因为在接受Revident治疗的患者中，即使在一个月后仍有显著效果，而在接受Flex Barrier治疗的组中则不然。此外，诺德兰-塔尔诺I类病变通常比II类病变改善更明显。
在这项概念验证性随机临床试验中，我们证明了Flex Barrier和Revident的临床适用性，尽管Revident比Flex Barrier的改善效果持续时间更长。需要进一步试验来优化治疗牙龈黑三角的多次应用方案。
