Mai Zhi-Ming, Lin Jia-Huang, Ngan Roger Kai-Cheong, Kwong Dora Lai-Wan, Ng Wai-Tong, Ng Alice Wan-Ying, Ip Kai-Ming, Chan Yap-Hang, Lee Anne Wing-Mui, Ho Sai-Yin, Lung Maria Li, Lam Tai-Hing
School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region (SAR), China.
Centre for Nasopharyngeal Carcinoma Research, Research Grants Council Area of Excellence Scheme, The University of Hong Kong, Hong Kong SAR, China.
Open Forum Infect Dis. 2020 Sep 12;7(10):ofaa426. doi: 10.1093/ofid/ofaa426. eCollection 2020 Oct.
We investigated the relationship of Epstein-Barr virus viral capsid antigen (EBV VCA-IgA) serostatus with ambient and personal ultraviolet radiation (UVR) and vitamin D exposure.
Using data from a multicenter case-control study, we included 1026 controls subjects in 2014-2017 in Hong Kong, China. Odds ratios (ORs) and 95% confidence intervals (CIs) of the association between UVR exposure and EBV VCA-IgA (seropositivity vs seronegativity) were calculated using unconditional logistic regression models adjusted for potential confounders.
We observed a large increase in seropositivity of EBV VCA-IgA in association with duration of sunlight exposures at both 10 years before recruitment and age 19-30 years (adjusted OR = 3.59, 95% CI = 1.46-8.77; and adjusted OR = 2.44, 95% CI = 1.04-5.73 for ≥8 vs <2 hours/day; for trend = .005 and .048, respectively). However, no association of EBV VCA-IgA serostatus with other indicators of UVR exposure was found. In addition, both circulating 25-hydroxyvitamin D (25OHD) and genetic predicted 25OHD were not associated with EBV VCA-IgA serostatus.
Our results suggest that personal UVR exposure may be associated with higher risk of EBV reactivation, but we did not find clear evidence of vitamin D exposure (observational or genetic), a molecular mediator of UVR exposure. Further prospective studies in other populations are needed to confirm this finding and to explore the underlying biological mechanisms. Information on photosensitizing agents, and serological markers of EBV, and biomarkers related to systemic immunity and inflammation should be collected and are also highly relevant in future studies.
我们研究了爱泼斯坦-巴尔病毒衣壳抗原（EBV VCA-IgA）血清状态与环境及个人紫外线辐射（UVR）和维生素D暴露之间的关系。
利用一项多中心病例对照研究的数据，我们纳入了2014 - 2017年在中国香港的1026名对照受试者。使用针对潜在混杂因素进行调整的无条件逻辑回归模型，计算UVR暴露与EBV VCA-IgA（血清阳性与血清阴性）之间关联的比值比（OR）和95%置信区间（CI）。
我们观察到，在招募前10年以及19 - 30岁时，EBV VCA-IgA血清阳性率随着阳光暴露时长的增加而大幅上升（对于每天暴露≥8小时与<2小时，调整后的OR = 3.59，95% CI = 1.46 - 8.77；调整后的OR = 2.44，95% CI = 1.04 - 5.73；趋势检验P值分别为0.005和0.048）。然而，未发现EBV VCA-IgA血清状态与UVR暴露的其他指标之间存在关联。此外，循环25-羟维生素D（25OHD）和基因预测的25OHD均与EBV VCA-IgA血清状态无关。
我们的结果表明，个人UVR暴露可能与EBV重新激活的较高风险相关，但我们未发现维生素D暴露（观察性或遗传性）这一UVR暴露的分子介质的明确证据。需要在其他人群中进行进一步的前瞻性研究以证实这一发现并探索潜在的生物学机制。应收集有关光敏剂、EBV血清学标志物以及与全身免疫和炎症相关的生物标志物信息，这些信息在未来研究中也具有高度相关性。
