Toribio Mabel, Burdo Tricia H, Fulda Evelynne S, Cetlin Madeline, Chu Sarah M, Feldpausch Meghan N, Robbins Gregory K, Neilan Tomas G, Melbourne Kathleen, Grinspoon Steven K, Zanni Markella V
Metabolism Unit, Division of Endocrinology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Department of Neuroscience, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania, USA.
Open Forum Infect Dis. 2020 Sep 29;7(10):ofaa459. doi: 10.1093/ofid/ofaa459. eCollection 2020 Oct.
The NOD-like receptor protein family pyrin domain containing 3 (NLRP3) inflammasome, activated in the setting of HIV, contributes to pro-atherogenic inflammation. Among antriretroviral therapy-naïve people with HIV (vs controls), levels of caspase-1-a key component of the NLRP3 inflammasome-were significantly increased. Six months of elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate significantly decreased caspase-1 levels in association with CD4+/CD8+ ratio recovery. . ClinicalTrials.gov NCT01766726.
在HIV感染情况下被激活的含pyrin结构域的NOD样受体蛋白家族3（NLRP3）炎性小体，会导致促动脉粥样硬化炎症。在未接受抗逆转录病毒治疗的HIV感染者（与对照组相比）中，NLRP3炎性小体的关键成分半胱天冬酶-1的水平显著升高。接受6个月的埃替拉韦/考比司他/恩曲他滨/替诺福韦酯富马酸盐治疗后，半胱天冬酶-1水平显著下降，同时CD4+/CD8+比值恢复。临床试验注册号：ClinicalTrials.gov NCT01766726。
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