长链非编码 RNA MALAT1 多态性与韩国人群胃癌风险的关联。

Association of long noncoding RNA MALAT1 polymorphisms with gastric cancer risk in Korean individuals.

机构信息

Clinical Trials Center, Chungnam National University Hospital, Daejeon, Republic of Korea.

Department of Pharmacology, Chungnam National University College of Medicine, Daejeon, Republic of Korea.

出版信息

Mol Genet Genomic Med. 2020 Dec;8(12):e1541. doi: 10.1002/mgg3.1541. Epub 2020 Nov 2.

DOI:10.1002/mgg3.1541

PMID:33135867

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7767557/

Abstract

BACKGROUND

Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) drives tumorigenesis of various human cancers. However, the association between MALAT1 variants and gastric cancer (GC) risk is unknown. We performed a case-control study to evaluate the possible association between rs619586 and rs3200401 SNPs in MALAT and GC risk.

METHODS

Samples from 458 patients with GC and 381 controls were genotyped using the TaqMan genotyping assay.

RESULTS

In stratified analyses, we observed that rs3200401 CT in the codominant model and CT+TT in the dominant model were associated with increased GC risk in male patients (CT: odds ratio [OR] = 1.81, 95% confidence interval [CI] = 1.09-3.01, p = 0.022; CT+TT: OR = 1.74, 95% CI = 1.07-2.83, p = 0.026), and the differentiated (CT: OR =1.79, 95% CI = 1.18-2.73, p = 0.007; CT+TT: OR = 1.76, 95% CI = 1.17-2.64, p = 0.007), and intestinal (CT: OR = 1.67, 95% CI = 1.11-2.49, p = 0.013; CT+TT: OR = 1.68, 95% CI = 1.14-2.47, p = 0.009) GC subgroups.

CONCLUSION

MALAT1 rs3200401 increases GC susceptibility and might affect GC development. Further studies are needed to validate our results in large populations and different ethnic groups.

摘要

背景

转移相关肺腺癌转录本 1（MALAT1）驱动各种人类癌症的肿瘤发生。然而，MALAT1 变体与胃癌（GC）风险之间的关联尚不清楚。我们进行了病例对照研究，以评估 MALAT 中 rs619586 和 rs3200401 SNP 与 GC 风险之间的可能关联。

方法

使用 TaqMan 基因分型检测试剂盒对 458 例 GC 患者和 381 例对照样本进行基因分型。

结果

在分层分析中，我们发现，在男性患者中，rs3200401 的共显性模型中的 CT 基因型和显性模型中的 CT+TT 基因型与 GC 风险增加相关（CT：比值比[OR] = 1.81，95%置信区间[CI] = 1.09-3.01，p = 0.022；CT+TT：OR = 1.74，95% CI = 1.07-2.83，p = 0.026），并且在分化（CT：OR = 1.79，95% CI = 1.18-2.73，p = 0.007；CT+TT：OR = 1.76，95% CI = 1.17-2.64，p = 0.007）和肠（CT：OR = 1.67，95% CI = 1.11-2.49，p = 0.013；CT+TT：OR = 1.68，95% CI = 1.14-2.47，p = 0.009）GC 亚组中也是如此。