性别、年龄和季节对临床健康宽吻海豚群体血液分析物变异的影响。
Effects of sex, age, and season on the variation of blood analytes in a clinically healthy population of bottlenose dolphins ( spp.).
机构信息
SeaWorld San Diego, San Diego, CA, USA.
Pacific Marine Mammal Center, Laguna Canyon Rd, Laguna Beach, CA, USA.
出版信息
Vet Q. 2020 Nov 9;40(1):342-352. doi: 10.1080/01652176.2020.1845415.
BACKGROUND
A comprehensive evaluation of the effects of sex, age, and season on blood analytes in a robust population size of bottlenose dolphins ( spp.) has not been investigated to date.
AIM
To define the variation in hematological and biochemical analytes of dolphins due to sex, age, and season.
METHODS
1,426 blood samples collected from 156 clinically normal dolphins consisting of 59 males and 97 females in which 37 analytes were measured were retrospectively identified. The dolphins were categorized by age, sex, and season, and categories were compared.
RESULTS
About 23 (64%) analytes differed by age. The number of differences between adjacent age groups decreased with advancing age. MPV, glucose, BUN, globulins, GGT and Cl progressively increased with age, whereas Abs lymphs, total protein, ALP, CK and Ca progressively decreased with age. Three (8%) of analytes differed between sex, whereas 16 (44%) analytes differed by season. Female dolphins had higher median iron (33 µmol/L) than male dolphins (25 µmol/L). Female dolphins also had higher Abs lymphs and MCHC, but Abs lymphs and MCHC also differed between age and season, respectively. Sex inconsistently and relatively infrequently influences analytes. Delphinids of advancing age experience immune senescence and decreasing renal perfusion or clearance.
CONCLUSIONS
These results demonstrate the importance of considering the influences of sex, age, and season on blood data, provide a baseline for accurate interpretation of clinicopathological analytes of delphinids in managed care, and will be useful for investigations into health, disease, and stressors of wild delphinids.
背景
迄今为止，尚未针对宽吻海豚（Tursiops truncatus）庞大的群体规模，全面评估性别、年龄和季节对血液分析物的影响。
目的
确定海豚血液分析物因性别、年龄和季节而发生的变化。
方法
回顾性鉴定了 156 只临床正常海豚（其中 59 只为雄性，97 只为雌性）的 1426 份血液样本，共测量了 37 项分析物。将海豚按年龄、性别和季节进行分类，并对各分类进行比较。
结果
约 23 项（64%）分析物的年龄存在差异。相邻年龄组之间的差异数量随着年龄的增长而减少。MPV、葡萄糖、BUN、球蛋白、GGT 和 Cl 随年龄逐渐增加，而 Abs 淋巴细胞、总蛋白、ALP、CK 和 Ca 则随年龄逐渐降低。3 项（8%）分析物的性别存在差异，而 16 项（44%）分析物的季节存在差异。雌性海豚的中位铁（33μmol/L）高于雄性海豚（25μmol/L）。雌性海豚的 Abs 淋巴细胞和 MCHC 也较高，但 Abs 淋巴细胞和 MCHC 也分别因年龄和季节而异。性别对分析物的影响不一致且相对较少。年龄较大的海豚经历免疫衰老和肾脏灌注或清除率下降。
结论
这些结果表明，在解释海豚的血液数据时，必须考虑性别、年龄和季节的影响，为管理护理中准确解释海豚的临床病理分析物提供了基准，并将有助于研究野生海豚的健康、疾病和应激源。
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