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遗传性出血性毛细血管扩张症患者舌部毛细血管扩张的治疗

Treatment of tongue telangiectasia in a patient with hereditary haemorrhagic telangiectasia.

作者信息

Bowers Eve Mandisa Rader, Lee Stella

机构信息

Otolaryngology, University of Pittsburgh Medical Center, Sewickley, Pennsylvania, USA.

Department of Otolaryngology-Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

出版信息

BMJ Case Rep. 2020 Nov 2;13(11):e238485. doi: 10.1136/bcr-2020-238485.

Abstract

A 61-year-old Caucasian woman presented to an outpatient otolaryngology clinic with increased bleeding from a dorsal tongue telangiectasia for 3 weeks. Her history was significant for hereditary haemorrhagic telangiectasia (HHT), a rare condition that causes vascular dysplasia, and recent symptomatic anaemia requiring blood transfusions. After failing medical management with topical haemostatic agents, she was offered and underwent surgical intervention to remove the tongue telangiectasia with duel therapy potassium titanyl phosphate (KTP) laser coblation and bevacizumab injections. A team of otolaryngologists removed the lesion without complications, and the patient denied bleeding, had minimal pain, and endorsed increased quality of life postoperatively. Tongue telangiectasias can cause life-threatening bleeding in some patients with HHT, and no surgical management guidelines exist to treat them. This case demonstrates the efficacy of KTP laser followed by bevacizumab injections in treating tongue telangiectasias in a patient with HHT.

摘要

一名61岁的白种女性因舌背毛细血管扩张出血增加3周,就诊于门诊耳鼻喉科诊所。她有遗传性出血性毛细血管扩张症(HHT)病史,这是一种罕见的导致血管发育异常的疾病,近期有症状性贫血需要输血。在用局部止血剂进行药物治疗失败后,她接受了手术干预,采用磷酸钛氧钾(KTP)激光消融联合贝伐单抗注射去除舌部毛细血管扩张症。一组耳鼻喉科医生成功切除病变,无并发症发生,患者术后无出血,疼痛轻微,生活质量有所提高。舌部毛细血管扩张症在一些HHT患者中可导致危及生命的出血,目前尚无治疗此类疾病的手术管理指南。本病例证明了KTP激光联合贝伐单抗注射治疗HHT患者舌部毛细血管扩张症的有效性。

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