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血管内治疗动脉-输尿管瘘。

Endovascular therapy of arterioureteral fistulas.

机构信息

Department of Diagnostic and Interventional Radiology, University Hospital Würzburg, Würzburg, Germany.

Department of Urology and Paediatric Urology, University Hospital Würzburg, Würzburg, Germany.

出版信息

Vasa. 2021 Apr;50(3):193-201. doi: 10.1024/0301-1526/a000922. Epub 2020 Nov 3.

DOI:10.1024/0301-1526/a000922
PMID:33140697
Abstract

: Arterioureteral fistulas (AUFs) are severe pathologies of different origin and with increasing incidence frequently appear in patients with underlying extensive malignancy and after pelvic surgery. AUF therapy is challenging since symptoms are frequently non-specific and patients are often unsuitable surgical candidates due to comorbidities. Since experiences with endovascular treatment strategies are limited, the feasibility, effectiveness, and safety were evaluated in a consecutive case series. : A retrospective analysis of five patients with endovascular AUF exclusion was performed. Probable predisposing factors for an AUF included history of pelvic malignancy with oncologic surgery in four patients, radiotherapy in four patients, and indwelling ureteral stents in four patients. Clinical presentation, diagnostic management, and site of fistula were assessed. Furthermore, technical and clinical success as well as complications were evaluated. : All patients presented with gross haematuria. In four patients, haematuria occurred during endoscopic ureteral stent manipulation. Affected vessels were the internal pudendal artery in one, intrarenal segmental artery and external iliac artery in two, and internal iliac artery in another two patients. Treatment included coil embolisation (n = 2), plug embolisation (n = 3), particulate embolisation (n = 1), and covered stent implantation (n = 2). Technical success was achieved in all procedures. In two cases, re-intervention was necessary due to AUF recurrence, resulting in a clinical success rate of 60.0%. One major complication class D was documented. : AUFs can be treated effectively and safely using endovascular techniques. Diagnostic and therapeutic management of this rare entity requires a high level of awareness for potential risk factors as well as an optimal multidisciplinary coordination.

摘要

动静脉瘘(AUF)是由不同病因引起的严重病变,发病率不断上升,常发生于广泛恶性肿瘤和盆腔手术后的患者。由于症状通常不具特异性,且患者常因合并症而不适合手术,AUF 的治疗极具挑战性。由于腔内治疗策略的经验有限,因此在连续病例系列中评估了其可行性、有效性和安全性。

对 5 例行血管内 AUF 排除的患者进行了回顾性分析。4 例患者有盆腔恶性肿瘤病史和肿瘤手术史,4 例患者有放射治疗史,4 例患者有留置输尿管支架史,这些可能是 AUF 的诱发因素。评估了临床症状、诊断处理和瘘管部位。此外,还评估了技术和临床成功率以及并发症。

所有患者均表现为肉眼血尿。4 例患者在进行输尿管支架内镜操作时出现血尿。受累血管分别为 1 例为阴部内动脉,2 例为肾内节段动脉和髂外动脉,另 2 例为髂内动脉。治疗包括线圈栓塞(n=2)、栓子栓塞(n=3)、微粒栓塞(n=1)和覆膜支架植入(n=2)。所有手术均达到技术成功。由于 AUF 复发,2 例需要再次介入,临床成功率为 60.0%。记录到 1 例严重并发症(D 级)。

血管内技术可有效且安全地治疗 AUF。这种罕见疾病的诊断和治疗管理需要高度警惕潜在的危险因素,并进行最佳的多学科协调。

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