Veterinary Teaching Hospital, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
J Vet Diagn Invest. 2020 Nov;32(6):953-956. doi: 10.1177/1040638720958767.
An 8-mo-old male African pygmy hedgehog was anorectic and ataxic; physical examination revealed tetraparesis and a gangrenous left hindlimb. Analgesic and supportive care were administered, but the animal died 3 d after presentation. Postmortem examination revealed a histiocytic sarcoma in a mesenteric lymph node with metastasis to several organs, multifocal vacuolation in the cerebral and cerebellar white matter, and a meningioma in the left lateral ventricle. We diagnosed wobbly hedgehog syndrome (WHS) with disseminated histiocytic sarcoma and lateral ventricular meningioma. Ventricular meningioma, a rare neoplasm in veterinary and human patients, has not been reported previously in hedgehogs, to our knowledge. The neurologic signs in our case were probably caused by the WHS-related vacuolar lesions and are consistent with those of reported WHS cases. Duration of illness was shorter than is typical of WHS cases, which might be related to the disseminated histiocytic sarcoma. Clinical relevance of the lateral ventricular meningioma was not evident because the ventricular mass was localized and not invasive.
一只 8 月龄雄性非洲迷你刺猬出现厌食和共济失调；体格检查发现四肢瘫痪和左后肢坏疽。给予了镇痛和支持治疗，但动物在就诊后 3 天死亡。尸检显示肠系膜淋巴结中有组织细胞肉瘤，并转移到多个器官，大脑和小脑白质多处空泡化，左侧侧脑室有脑膜瘤。我们诊断为摇摆刺猬综合征（WHS）伴播散性组织细胞肉瘤和侧脑室脑膜瘤。脑室脑膜瘤在兽医和人类患者中是一种罕见的肿瘤，据我们所知，以前在刺猬中尚未有报道。本病例的神经症状可能是由 WHS 相关的空泡性病变引起的，与已报道的 WHS 病例一致。疾病持续时间短于典型的 WHS 病例，这可能与播散性组织细胞肉瘤有关。侧脑室脑膜瘤的临床意义并不明显，因为脑室肿块局限且无侵袭性。
