根据肿瘤倍增时间，手术切除对结直肠癌异时性转移的影响。
Impact of Surgical Resection on Metachronous Metastases of Colorectal Cancer According to Tumor Doubling Time.
机构信息
Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan
Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan.
出版信息
In Vivo. 2020 Nov-Dec;34(6):3367-3374. doi: 10.21873/invivo.12175.
BACKGROUND/AIM: We aimed to elucidate the prognostic impact of tumor doubling time (DT) and radical surgery when classified by DT in patients with metachronous liver, lung, or peritoneal metastases of colorectal cancer (CRC).
PATIENTS AND METHODS
We reviewed the data of 1941 patients who underwent curative surgery for CRC and calculated DT for recurrences using computed tomography.
RESULTS
Short DT was an independent prognostic risk factor in liver (p<0.001) and peritoneal (p=0.03) metastases. Survival was significantly better in patients who underwent surgery than in those who did not, both in short and long DT groups in any metastatic organ (p<0.01). Patients with long DT gained significantly better prognostic benefit from surgery than those with short DT in liver (p=0.01) and peritoneal (p=0.04) metastases.
CONCLUSION
Surgery is recommended for resectable metastases, especially in patients with liver and peritoneal metastases with long DT.
背景/目的：我们旨在阐明肿瘤倍增时间（DT）和根治性手术的预后影响，当按 DT 对结直肠癌（CRC）的肝、肺或腹膜转移的患者进行分类时。
患者和方法
我们回顾了 1941 名接受结直肠癌根治性手术的患者的数据，并使用计算机断层扫描计算复发的 DT。
结果
短 DT 是肝（p<0.001）和腹膜（p=0.03）转移的独立预后危险因素。与未接受手术的患者相比，在任何转移器官中，接受手术的患者在短 DT 和长 DT 组中的生存均显著改善（p<0.01）。在肝（p=0.01）和腹膜（p=0.04）转移中，长 DT 患者从手术中获得的预后获益明显优于短 DT 患者。
结论
建议对可切除的转移灶进行手术，特别是对于具有长 DT 的肝和腹膜转移的患者。
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