孕酮受体表达及评分差异在确定脑膜瘤分级和亚型中的作用
Progesterone Receptor Expression and Score Differences in Determining Grade and Subtype of Meningioma.
作者信息
Poniman Jeni, Cangara Muh Husni, Kaelan Cahyono, Miskad Upik A, Arsyadi Gunawan, Ghaznawe Mahmud, Daud Dasril, Ihwan Andi, Rosyidi Rohadi Muhammad
机构信息
Department of Anatomical Pathology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.
Faculty of Medicine, Muhammadiyah University, Makassar, Indonesia.
出版信息
J Neurosci Rural Pract. 2020 Oct;11(4):552-557. doi: 10.1055/s-0040-1714043. Epub 2020 Jul 13.
Meningioma is the most common brain tumor in which therapy and monitoring depend on the histopathological grade (World Health Organization [WHO] Grade). Progesterone receptor (PR) expression was reported positive in meningothelial cells and meningiomas with various degrees of positivity. We evaluated PR expression to determine its correlation with WHO Grade and each subtype of meningioma. This study used 70 samples of paraffin block that were diagnosed as meningioma and classified into WHO Grade I, II, and III. The paraffin blocks were sectioned in 5 µm thickness and immunohistochemically stained with the anti-PR antibody. PR expression was found positive in WHO Grade I and II groups, but negative in WHO Grade III group with the score of +2 found in clear cell and atypical subtype. These results were statistically significant with -value < 0.05. PR can be used as an additional marker to determine WHO Grade and subtype of meningioma.
脑膜瘤是最常见的脑肿瘤，其治疗和监测取决于组织病理学分级（世界卫生组织[WHO]分级）。据报道，孕激素受体（PR）在脑膜内皮细胞和不同阳性程度的脑膜瘤中呈阳性表达。我们评估了PR表达，以确定其与WHO分级及脑膜瘤各亚型的相关性。 本研究使用了70份石蜡块样本，这些样本被诊断为脑膜瘤，并分为WHO I级、II级和III级。将石蜡块切成5微米厚的切片，并用抗PR抗体进行免疫组织化学染色。 PR表达在WHO I级和II级组中呈阳性，但在WHO III级组中呈阴性，在透明细胞和非典型亚型中评分为+2。这些结果具有统计学意义，P值<0.05。 PR可作为确定脑膜瘤WHO分级和亚型的额外标志物。
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