Department of Biosystems, Laboratory of Gene Technology, KU Leuven, Leuven, Belgium.
Environ Microbiol. 2020 Dec;22(12):4895-4908. doi: 10.1111/1462-2920.15302. Epub 2020 Nov 25.
The immune response to SARS-CoV-2 reveals a delicate balance between protective effects and harmful pathological reactions and can possibly explain the highly variable disease manifestations in subjects infected with this novel coronavirus. A better understanding of the anti-viral immune response is not only critical for vaccine development but might also provide targets for pharmaceutical and immunological treatment options. Recent research literature on immune aspects of COVID-19 is summarized in this review with an outlook how bats have evolved to live with these viral infections.
对 SARS-CoV-2 的免疫反应揭示了保护性作用和有害病理反应之间的微妙平衡,这可能解释了感染这种新型冠状病毒的个体中高度可变的疾病表现。更好地了解抗病毒免疫反应不仅对疫苗开发至关重要,而且可能为药物和免疫治疗选择提供靶点。本文综述了 COVID-19 免疫方面的最新研究文献,并展望了蝙蝠是如何进化来应对这些病毒感染的。