Departments of Medicinal Chemistry and Bioengineering, University of Utah, Salt Lake City, UT 84112, USA.
Chem Commun (Camb). 2020 Nov 19;56(92):14423-14426. doi: 10.1039/d0cc05893a.
To map the cellular topography of the rare 3-O-sulfated structural motif of heparan sulfate (HS), we constructed quantum dot-based probes for antithrombin and FGF2, which reveal widely different distribution of the targeted HS motifs. The technology helps show that old and young aortic endothelia display widely different levels of the antithrombin-binding 3-O-sulfated HS motif.
为了绘制肝素硫酸（HS）中罕见的 3-O-硫酸结构基序的细胞拓扑图，我们构建了针对抗凝血酶和 FGF2 的量子点探针，这些探针揭示了靶向 HS 基序的广泛不同的分布。该技术有助于表明，老年和年轻的主动脉内皮细胞显示出广泛不同水平的抗凝血酶结合 3-O-硫酸 HS 基序。
