Lejeune F J
Institut Jules Bordet, Bruxelles, Belgium.
Anticancer Res. 1987 Jul-Aug;7(4B):701-5.
Adjuvant treatments following surgery include nonsurgical and surgical approaches which should be compared to a randomized control. Between the years 1978 and 1986, we identified 21 randomized trials on stage I primary melanoma, using 2,850 patients. None of the systemic chemotherapy, immunotherapy or chemo-immunotherapy protocols improved the results. However, prophylactic isolation perfusion of the limbs with cytostatics represents a promising approach and is currently studied in our international prospective randomized trial (EORTC, WHO, NAPG-NCI) In stage II--regional metastases--15 studies including 1972 patients have been reported. None of the systemic regimen was found efficient. The reasons for these failures are discussed and future approaches are presented.
手术后的辅助治疗包括非手术和手术方法,应与随机对照进行比较。在1978年至1986年期间,我们通过2850例患者确定了21项关于I期原发性黑色素瘤的随机试验。没有一种全身化疗、免疫疗法或化学免疫疗法方案能改善结果。然而,用细胞抑制剂对肢体进行预防性隔离灌注是一种有前景的方法,目前正在我们的国际前瞻性随机试验(欧洲癌症研究与治疗组织、世界卫生组织、北美黑色素瘤研究组-美国国立癌症研究所)中进行研究。在II期——区域转移——已报告了15项研究,涉及1972例患者。没有发现任何全身治疗方案有效。讨论了这些失败的原因并提出了未来的方法。