双膦酸盐对环孢素诱导的牙槽骨丧失的保骨作用：一项动物研究。
Bone Sparing Effects of Bisphosphonates in Cyclosporine-induced Alveolar Bone Loss: An Animal Study.
作者信息
Bhat Sneha R, Shwetha Rajanna, Boloor Vinita A, Kini Shravan R, Kudva Aravind R
机构信息
Department of Periodontics, Yenepoya Dental College, Mangalore, Karnataka, India.
Department of Conservative Dentistry and Endodontics, GDC, Bangalore, Karnataka, India.
出版信息
J Pharm Bioallied Sci. 2020 Aug;12(Suppl 1):S560-S563. doi: 10.4103/jpbs.JPBS_171_20. Epub 2020 Aug 28.
Various pharmacological agents are known to create an imbalance in the normal physiology of bone remodeling. Cyclosporine-A (Cs-A) is one of the drugs that is widely used in transplantation and has its main side effect as gingival hyperplasia and alveolar bone loss by their action on the inflammatory mediators. Bisphosphonates are a new class of drugs that inhibit bone resorption by decreasing the osteoclast activity and number. The aim of this study was to evaluate the effect of concomitant administration of alendronate on Cs-A-induced alveolar bone loss in a rat model.
已知多种药理剂会破坏骨重塑正常生理过程中的平衡。环孢素A（Cs-A）是一种广泛用于移植的药物，其主要副作用是通过作用于炎症介质导致牙龈增生和牙槽骨丧失。双膦酸盐是一类新型药物，可通过降低破骨细胞活性和数量来抑制骨吸收。本研究的目的是评估在大鼠模型中同时给予阿仑膦酸钠对Cs-A诱导的牙槽骨丧失的影响。
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