DBU 促进的多取代给体-受体环丙烷的开环反应：具有季碳原子的官能化查耳酮的合成。
DBU-promoted ring-opening reactions of multi-substituted donor-acceptor cyclopropanes: access to functionalized chalcones with a quaternary carbon group.
机构信息
School of Chemistry and Chemical Engineering, Yangzhou University, 180 Siwangting Street, Yangzhou 225002, P. R. China.
出版信息
Org Biomol Chem. 2020 Nov 25;18(45):9210-9215. doi: 10.1039/d0ob01895c.
PMID:33150917
Abstract
A convenient and straightforward strategy to synthesize Z-configuration chalcones with alkylcyanoacetate subunits via DBU-promoted ring-opening reactions of multi-substituted D-A cyclopropanes has been developed. This reaction did not require a transition metal catalyst and extra solvent, and haloalkanes acted as both an alkylation reagent and solvent.
摘要
通过 DBU 促进多取代 D-A 环丙烷的开环反应，开发了一种方便直接的方法来合成具有烷基氰乙酸酯单元的 Z-构型查尔酮。该反应不需要过渡金属催化剂和额外的溶剂，而卤代烷烃既作为烷基化试剂又作为溶剂。
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