Mahapatra Annuroopa, Nayak Rashmita, Satpathy Anurag, Pati Basanta Kumar, Mohanty Rinkee, Mohanty Gatha, Beura Rajdeep
Department of Periodontics, SCB Dental College and Hospital, Cuttack, Odisha, India.
Department of Periodontics and Oral Implantology, Institute of Dental Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India.
J Periodontol. 2021 Aug;92(8):1107-1116. doi: 10.1002/JPER.20-0266. Epub 2020 Nov 23.
Periodontal disease and pregnancy outcomes have been claimed to be associated with conflicting reports. The purpose of this study was to prospectively examine the association between maternal periodontal status, oral inflammatory load and serum C- reactive protein (CRP) level, and infant birth weight.
A total of 156 pregnant women (age 26.62 ± 3.93 years) within the gestational age group of 13 to 32 weeks participated in this cross-sectional study. Oral inflammatory load (OIL) was assessed in a salivary rinse sample using fluorescence microscopy. Clinical periodontal parameters were recorded and serum C-reactive protein level (CRP) was assessed. Participants were followed till delivery, details of parturition and infant birth weight (IBW) was recorded.
OIL was significantly more in participants with mild and moderate periodontitis as compared to those with gingivitis in mid and late stages of pregnancy. Periodontal and systemic inflammatory parameters were positively correlated. A significant negative correlation was found between IBW and OIL (P = 0.006) and serum CRP (P < 0.001). The GI score (P = 0.039), BOP% (P = 0.023), serum CRP level (P < 0.001) and oral polymorphonuclear neutrophil (oPMN) count (P < 0.001) was significantly more in mothers delivering babies with low IBW. A multiple linear regression analysis showed that only oPMN (β = - 0.244, P = 0.021) and serum CRP (β = - 0.226, P = 0.019) were included in the best model (R = 0.12, F(3,152) = 7.15, P < 0.001) for significantly predicting the infant birth weight.
Poor maternal periodontal status, increased oral inflammatory load and increased systemic inflammation have an adverse effect on infant birth weight.
牙周疾病与妊娠结局之间的关系一直存在相互矛盾的报道。本研究的目的是前瞻性地研究孕妇牙周状况、口腔炎症负荷和血清C反应蛋白（CRP）水平与婴儿出生体重之间的关联。
共有156名孕周在13至32周的孕妇（年龄26.62±3.93岁）参与了这项横断面研究。使用荧光显微镜在唾液冲洗样本中评估口腔炎症负荷（OIL）。记录临床牙周参数并评估血清C反应蛋白水平（CRP）。对参与者进行随访直至分娩，记录分娩细节和婴儿出生体重（IBW）。
与妊娠中晚期患有牙龈炎的参与者相比，患有轻度和中度牙周炎的参与者的OIL明显更高。牙周和全身炎症参数呈正相关。发现IBW与OIL（P = 0.006）和血清CRP（P < 0.001）之间存在显著负相关。分娩低体重儿的母亲的牙龈指数（GI）评分（P = 0.039）、探诊出血百分比（BOP%）（P = 0.023）、血清CRP水平（P < 0.001）和口腔多形核中性粒细胞（oPMN）计数（P < 0.001）明显更高。多元线性回归分析表明，只有oPMN（β = - 0.244，P = 0.021）和血清CRP（β = - 0.226，P = 0.019）被纳入最佳模型（R = 0.12，F(3,152) = 7.15，P < 0.001），用于显著预测婴儿出生体重。
孕妇牙周状况不佳、口腔炎症负荷增加和全身炎症增加对婴儿出生体重有不利影响。
