半乳糖凝集素-1、-3、-7、-8 和 -9 作为上皮性卵巢癌生存预后标志物的系统评价和荟萃分析。

Galectins-1, -3, -7, -8 and -9 as prognostic markers for survival in epithelial ovarian cancer: A systematic review and meta-analysis.

机构信息

Laboratory of Experimental Surgery and Surgical Research NS Christeas, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

出版信息

Int J Gynaecol Obstet. 2021 Mar;152(3):299-307. doi: 10.1002/ijgo.13471. Epub 2020 Dec 25.

DOI:10.1002/ijgo.13471

PMID:33156523

Abstract

BACKGROUND

Galectins are a family of proteins that have recently emerged as regulators of cancer biology.

OBJECTIVES

To investigate the impact of peritumoral and tumoral galectin expression on ovarian cancer prognosis.

SEARCH STRATEGY

We searched Medline, Cochrane, and EMBASE databases from inception until March 22, 2020.

SELECTION CRITERIA

All studies correlating galectins and ovarian cancer prognosis were selected.

DATA COLLECTION AND ANALYSIS

The literature search presented 11 studies, which contained 1034 patients. Meta-analysis was performed with RevMan 5.3 software.

MAIN RESULTS

Studies were stratified into two groups depending on the location of galectin expression (peritumoral stroma or nucleus/cytoplasm of tumor cells). Tumoral galectin-7 and galectin-9 expression was significantly associated with poor overall survival (odds ratio [OR] 2.06, 95% confidence interval [CI] 1.32-3.21, P = 0.001; OR 1.71, 95% CI 1.27-2.30, P < 0.001, respectively). The total effect of high tumoral expression of galectins in overall survival and progression-free survival was significant (OR 1.51, 95% CI 1.02-2.23, P = 0.04; OR 2.76, 95% CI 1.73-4.40, P < 0.001, respectively).

CONCLUSIONS

Our results suggest that galectins are implicated in ovarian cancer prognosis; however, further research is needed to ascertain their actual importance as well as their diagnostic accuracy.

摘要

背景

半乳糖凝集素是一类蛋白质，最近被认为是癌症生物学的调控因子。

目的

研究肿瘤周围和肿瘤内半乳糖凝集素表达对卵巢癌预后的影响。

检索策略

我们检索了 Medline、Cochrane 和 EMBASE 数据库，检索时间截至 2020 年 3 月 22 日。

选择标准

所有与半乳糖凝集素和卵巢癌预后相关的研究均被纳入。

数据收集和分析

文献检索共呈现了 11 项研究，包含 1034 名患者。使用 RevMan 5.3 软件进行荟萃分析。

主要结果

根据半乳糖凝集素表达的位置（肿瘤周围基质或肿瘤细胞的核/细胞质）将研究分为两组。肿瘤中 galectin-7 和 galectin-9 的表达与总生存期不良显著相关（比值比 [OR] 2.06，95%置信区间 [CI] 1.32-3.21，P = 0.001；OR 1.71，95% CI 1.27-2.30，P < 0.001）。高肿瘤中 galectin 总体表达对总生存期和无进展生存期的总效应具有统计学意义（OR 1.51，95% CI 1.02-2.23，P = 0.04；OR 2.76，95% CI 1.73-4.40，P < 0.001）。