铑催化苯甲酸、甲醛和丙二酸酯通过氢芳基化反应合成茚酮。
Rh-Catalyzed Annulation of Benzoic Acids, Formaldehyde, and Malonates via -Hydroarylation to Indanones.
作者信息
Yu Shuling, Lv Ningning, Hong Chao, Liu Zhanxiang, Zhang Yuhong
机构信息
Department of Chemistry, Zhejiang University, Hangzhou 310027, China.
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China.
出版信息
Org Lett. 2020 Nov 6;22(21):8354-8358. doi: 10.1021/acs.orglett.0c02986. Epub 2020 Oct 14.
A three-component reaction from readily available low-cost materials of benzoic acids, formaldehyde, and malonates for the preparation of indanones by rhodium catalysis is reported. The annulation is initiated by an -hydroarylation of benzoic acids, and a Lewis acid is not required. The solvent has a significant influence to the reaction, and 2-substituted or nonsubstituted indanones are obtained by the change of solvent.
报道了一种由铑催化的、从苯甲酸、甲醛和丙二酸酯等易得的低成本原料出发的三组分反应，用于制备茚满酮。环化反应由苯甲酸的α-氢芳基化引发，且不需要路易斯酸。溶剂对反应有显著影响，通过改变溶剂可得到2-取代或未取代的茚满酮。
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