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本文引用的文献

1
Anti-Jk that are detected by solid-phase red blood cell adherence but missed by gel testing can cause hemolytic transfusion reactions.通过固相红细胞黏附检测到但凝胶试验漏检的抗Jk可导致溶血性输血反应。
Transfusion. 2016 Dec;56(12):2973-2979. doi: 10.1111/trf.13782. Epub 2016 Sep 5.
2
Further evidence for naturally occurring anti Jk(a) antibodies.天然存在的抗Jk(a)抗体的进一步证据。
Asian J Transfus Sci. 2015 Jan-Jun;9(1):107. doi: 10.4103/0973-6247.150975.
3
Naturally occurring anti-Jk(a).天然存在的抗Jk(a)。
Transfusion. 2005 Jun;45(6):1043-4. doi: 10.1111/j.1537-2995.2005.00333.x.
4
Naturally-occurring anti-Jka in infant twins.婴儿双胞胎中天然存在的抗Jka抗体。
Immunohematology. 1999;15(4):159-62.
5
Clinical and laboratory findings on two patients with naturally occurring anti-Kell agglutinins.两名天然存在抗凯尔凝集素患者的临床及实验室检查结果。
Transfusion. 1981 Mar-Apr;21(2):184-8. doi: 10.1046/j.1537-2995.1981.21281178154.x.
6
"Naturally-occurring" anti-K1: possible association with mycobacterium infection.“自然产生的”抗K1：与分枝杆菌感染的可能关联。
Transfusion. 1978 Jul-Aug;18(4):472-3. doi: 10.1046/j.1537-2995.1978.18478251244.x.

一例罕见的天然产生的抗Jk(a)抗体在试管法手工筛查试验中漏检的病例。

A rare case of naturally occurring allo anti-Jk(a) missed in manual screening test on tube method.

作者信息

Kanani Ashish N, Senjaliya Snehal B, Rajapara Manisha M, Gupta Anurag K, Joshi Sanmukh R

机构信息

Lok Samarpan Regional Blood Center, Surat, Gujarat, India.

Department of Application, Immucor (India), New Delhi, India.

出版信息

Asian J Transfus Sci. 2020 Jan-Jun;14(1):60-62. doi: 10.4103/ajts.AJTS_104_19. Epub 2020 Jul 24.

DOI:10.4103/ajts.AJTS_104_19
PMID:33162709
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7607994/
Abstract

BACKGROUND

Antibodies to the Kidd blood group are mainly red blood cell (RBC) immune, but a few reports on naturally occurring antibodies have been documented.

AIM

The aim of this study is to study the anti-Jk(a) for its unusual reactivity with different serological methods.

MATERIALS AND METHODS

Donor's plasma was tested with RBCs from in house donors and commercial panels by manual and automated devices.

RESULTS

A 36-year-old male blood donor with naturally occurring anti-Jk(a) is detected by solid-phase assays and the gel card technique but not by the tube method. The IgG antibody with the titer of >32 was not a complement-fixing hemolysin, showed a reduced reactivity with enzyme-treated RBCs, and was detectable through 8 months' follow-up period. The donor was typed as (Jk(a-).

CONCLUSION

An unusual naturally occurring anti-Jk(a) detected by solid-phase red-cell adherence but not reacting by tube technique reflected on the sensitivity of the methods used.

摘要

背景

抗基德血型抗体主要是红细胞免疫性的，但已有少数关于天然存在抗体的报道。

目的

本研究旨在研究抗-Jk(a)抗体在不同血清学方法下的异常反应性。

材料与方法

用手工和自动化设备，将供者血浆与来自内部供者的红细胞及商业红细胞面板进行检测。

结果

通过固相检测法和凝胶卡技术检测到一名36岁男性献血者天然存在抗-Jk(a)抗体，但试管法未检测到。效价>32的IgG抗体不是补体结合溶血素，与酶处理的红细胞反应性降低，且在8个月的随访期内均可检测到。该供者血型为Jk(a-)。

结论

通过固相红细胞黏附法检测到的一种异常天然抗-Jk(a)抗体，而试管法未检测到，这反映了所用方法的敏感性。