Kafula Maria N, Ugburo Emmanuel, Kibuule Dan
School of Pharmacy, Faculty of Health Sciences, University of Namibia, Windhoek Namibia.
Afr Health Sci. 2020 Jun;20(2):1000-1010. doi: 10.4314/ahs.v20i2.57.
In Namibia, the burden of mental illnesses is estimated at 25.6% and is expected to double by 2025. Few studies in sub-Saharan Africa estimate the consumption rates of psychotropic medicines as a proxy of irrational use.
The consumption rate of psychotropic medicines at a referral hospital was determined.
A hospital-based retrospective medicine utilization analysis of Facility Electronic Stock Card (FESC) psychotropic medication was conducted at Intermediate Hospital Katutura over a 7 year period, 2011-2017. Data on consumption and expenditure on psychotropic medicines were abstracted from FESC and analysed using descriptive statistics in SPSS v22. The main outcomes were consumption rates, daily Defined Dose, (DDD) and/or expenditure.
Of the 580 351,4 DDD of psychotropic medicines consumed, 84% were anti-psychotics, 9.2% anti-depressants and 6.8% anxiolytics. Anti-psychotics (48.8%) and anxiolytics (47.9%) had the highest consumption by cost relative to anti-depressants (3.3%). The most consumed antidepressants were imipramine (62%) by DDD and fluoxetine (55.8%) by cost. The most consumed anti-psychotics were chlorpromazine (74.6%) by DDD and haloperidol (68.4%) by cost respectively. Diazepam (79.4%) and hydroxyzine (94.2%) were most consumed sedative-hypnotics by DDD and cost respectively.
The consumption of new psychotropics contributes to higher costs. There is need for cost-effectiveness analysis of new versus conventional psychotropics to optimize treatment, outcomes and costs.
在纳米比亚,精神疾病负担估计为25.6%,预计到2025年将翻倍。撒哈拉以南非洲地区很少有研究将精神药物的消费率作为不合理使用的指标进行估算。
确定一家转诊医院精神药物的消费率。
2011年至2017年期间,在卡图图拉中级医院对设施电子库存卡(FESC)中的精神药物进行了基于医院的回顾性药物使用分析。从FESC中提取精神药物的消费和支出数据,并使用SPSS v22中的描述性统计进行分析。主要结果是消费率、每日限定剂量(DDD)和/或支出。
在消费的580351.4 DDD精神药物中,84%为抗精神病药物,9.2%为抗抑郁药物,6.8%为抗焦虑药物。相对于抗抑郁药物(3.3%),抗精神病药物(48.8%)和抗焦虑药物(47.9%)按成本计算的消费量最高。按DDD计算,最常用的抗抑郁药物是丙咪嗪(62%),按成本计算是氟西汀(55.8%)。按DDD计算,最常用的抗精神病药物是氯丙嗪(74.6%),按成本计算是氟哌啶醇(68.4%)。地西泮(79.4%)和羟嗪(94.2%)分别是按DDD和成本计算消费量最高的镇静催眠药。
新型精神药物的消费导致成本更高。需要对新型与传统精神药物进行成本效益分析以优化治疗、结果和成本。