Biomedical and Public Health Department, Institut de Recherche en Sciences de la Santé, Direction Regionale, Avenue de la liberté, 01 BP 545, Bobo-Dioulasso 01, Burkina Faso.
Department of Applied Biology, Université Nazi Boni, 01 BP 1091 Bobo-Dioulasso 01, Burkina Faso.
J Med Entomol. 2021 Mar 12;58(2):781-786. doi: 10.1093/jme/tjaa240.
Indoor residual spraying (IRS) was applied in addition to the use of long-lasting insecticidal nets in the South West in Burkina Faso, where Anopheles gambiae s.l. the major malaria vector was resistant to pyrethroids. This study was designed to evaluate the efficacy and residual life of bendiocarb (active ingredient) used for spraying on different wall surfaces (mud and cement). Cone bioassays were done monthly with the susceptible An. gambiae 'Kisumu' strain and the local wild populations to determine the duration for which insecticide was effective in killing mosquitoes. Cone bioassay data showed low efficacy and short persistence of bendiocarb applied on mud and cement walls, lasting 2 mo with the susceptible insectary strain and less than 1 mo with An. gambiae wild populations. In addition, WHO tube assays confirmed resistance of An. gambiae wild populations to 0.1% bendiocarb with mortality rates less than 80% in both study sites (sprayed and unsprayed sites). The pilot study of IRS with bendiocarb showed that the residual efficacy of bendiocarb was very short, and resistance to bendiocarb was confirmed in wild populations of An. gambiae s.l. Therefore, Ficam 80 WP was not suitable for IRS in this area due to the short residual duration related mainly to vectors resistance to bendiocarb. While waiting for innovative malaria control tool, alternative insecticide (organophosphate or neonicotinoid classes) or combinations of insecticides have to be used for insecticide resistance management in Burkina Faso.
在布基纳法索西南部，在使用长效驱虫蚊帐的基础上，还采用了室内滞留喷洒（IRS）措施，当地主要的疟疾传播媒介冈比亚按蚊对拟除虫菊酯类杀虫剂产生了抗药性。本研究旨在评估用于喷洒在不同墙壁表面（泥墙和水泥墙）上的苯氧威（有效成分）的功效和残留寿命。每月使用敏感的冈比亚按蚊“基苏木”品系和当地野生种群进行锥形生物测定，以确定杀虫剂杀死蚊子的有效持续时间。锥形生物测定数据显示，苯氧威在泥墙和水泥墙上的效果差，持效期短，对敏感的昆虫饲养品系的有效持续时间为 2 个月，对冈比亚按蚊野生种群的有效持续时间不到 1 个月。此外，世界卫生组织管测试验证实了冈比亚按蚊野生种群对 0.1%苯氧威的抗药性，在两个研究地点（喷洒和未喷洒地点）的死亡率均低于 80%。苯氧威 IRS 的试点研究表明，苯氧威的残留效果非常短暂，而且在冈比亚按蚊的野生种群中证实了对苯氧威的抗药性。因此，由于与载体对苯氧威的抗药性有关的残留持续时间较短，Ficam 80 WP 不适合在该地区用于 IRS。在等待创新的疟疾控制工具的同时，必须在布基纳法索使用替代杀虫剂（有机磷类或新烟碱类）或杀虫剂组合来进行杀虫剂抗性管理。
