School of Pharmacy, Jiangsu Key Laboratory of Inflammation and Molecular Drug Targets, Nantong University, Nantong, Jiangsu Province 226001, China.
J Mater Chem B. 2020 Dec 28;8(48):10954-10965. doi: 10.1039/d0tb01939a. Epub 2020 Nov 11.
Inflammation is ubiquitous in the body, and uncontrolled inflammation often contributes to various diseases. Celastrol, a compound isolated from a Chinese medicinal herb, holds great potential in treating multiple inflammation-associated diseases. However, its further clinical use is limited by its poor solubility, bioavailability, and high organ toxicity. With the advancement of nanotechnology, the nano-delivery of celastrol can effectively improve its oral bioavailability, maximize its efficacy and minimize its side effects. Here, we summarize the roles of celastrol in the treatment of various inflammation-associated diseases, with a special emphasis on its role in modulating immune cell signaling or non-immune cell signaling within the inflammatory microenvironment, and we highlight the latest advances in nano-delivery strategies for celastrol to treat diseases associated with inflammation.
炎症在体内无处不在，失控的炎症常常导致各种疾病。从一种中药中分离出来的化合物雷公藤红素在治疗多种炎症相关疾病方面具有很大的潜力。然而，由于其溶解度差、生物利用度低和高器官毒性，其进一步的临床应用受到限制。随着纳米技术的进步，雷公藤红素的纳米递药可以有效地提高其口服生物利用度，最大限度地发挥其疗效，最小化其副作用。在这里，我们总结了雷公藤红素在治疗各种炎症相关疾病中的作用，特别强调了它在调节炎症微环境中的免疫细胞信号或非免疫细胞信号方面的作用，并强调了雷公藤红素用于治疗炎症相关疾病的最新纳米递药策略的进展。
