Grecchi C, Sarda C, Manciulli T, Scudeller L, Leoni C, Mariani B, Cambieri P, Chinellato F E, Aquino I M G, Marone P, Ancarani C, Astroni L, Muzzi A, Brunetti E, Novati S
Postgraduate School of Infectious and Tropical Diseases, Department of Internal Medicine, University of Pavia, Pavia, Italy.
PhD School of Experimental Medicine, University of Pavia, Pavia, Italy - Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.
Ann Ig. 2020 Nov-Dec;32(6):682-688. doi: 10.7416/ai.2020.2388.
The management of Latent Tuberculosis Infection is crucial in fighting Tuberculosis worldwide, and particularly in low incidence European Countries. While guidelines for the management of Tuberculosis in newly arrived immigrants have been issued by the European Center for Disease Control and Prevention and by the National Health Authorities in Italy, these are not widely implemented yet at local level.
We report our program for the screening of Latent Tuberculosis Infection and active Tuberculosis in asylum seekers, jointly implemented by Public Health Authorities and the Infectious Diseases Department of a tertiary care, teaching hospital in Northern Italy.
We reviewed records of the asylum seekers who were screened at our center via Tuberculin Skin Test and/or Interferon Gamma Release Assay plus chest X-ray and either treated with Isoniazid Preventive Treatment or for active Tuberculosis Disease in case of positive results.
We screened 726 migrants, mostly males (97.3%) and from Sub-Saharan Africa (82.2%) and found a high adherence rate for both screening (98.2%) and Isoniazid Preventive Treatment (90.1%). In addition, we found seven cases of active Tuberculosis.
Latent Tuberculosis Infection screening and treatment proved feasible in our program, which should be systematically implemented in asylum seekers reaching Europe.
潜伏性结核感染的管理对于全球抗击结核病至关重要，在结核病低发的欧洲国家尤为如此。虽然欧洲疾病预防控制中心和意大利国家卫生当局已发布了针对新抵达移民的结核病管理指南，但这些指南在地方层面尚未得到广泛实施。
我们报告了由意大利北部一家三级护理教学医院的公共卫生当局和传染病科联合实施的针对寻求庇护者的潜伏性结核感染和活动性结核病筛查项目。
我们回顾了在我们中心通过结核菌素皮肤试验和/或干扰素γ释放试验加胸部X光进行筛查，并在结果呈阳性时接受异烟肼预防性治疗或活动性结核病治疗的寻求庇护者的记录。
我们筛查了726名移民，其中大多数为男性（97.3%），来自撒哈拉以南非洲（82.2%），发现筛查（98.2%）和异烟肼预防性治疗（90.1%）的依从率都很高。此外，我们发现了7例活动性结核病病例。
在我们的项目中，潜伏性结核感染筛查和治疗被证明是可行的，该项目应在抵达欧洲的寻求庇护者中系统实施。
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