丙戊酸对多环芳烃环境致癌物诱导的肿瘤发生的干预作用。
The intervention of valproic acid on the tumorigenesis induced by an environmental carcinogen of PAHs.
作者信息
Peng Junxuan, Cai Zuchao, Zhao Ruixue, Chen Jiahao, Liu Guochao, Dong Chao, Lim David, Feng Zhihui
机构信息
Department of Occupational Health and Occupational Medicine, School of Public Health, Cheeloo College of Medicine, Shandong University, 44 Wenhua Xi Road, Shandong, Jinan, 250012, China.
School of Science and Health, Western Sydney University, Narellan Road, Campbelltown NSW 2560, Australia.
出版信息
Toxicol Res (Camb). 2020 Aug 31;9(5):609-621. doi: 10.1093/toxres/tfaa069. eCollection 2020 Sep.
This study investigated whether valproic acid (VPA, a histone deacetylase inhibitor) can interfere with the carcinogenicity of polycyclic aromatic hydrocarbons (PAHs). A typical representative compound of PAHs, 7,12-Dimethylbenz[a]anthracene (DMBA), was used to induce rat breast cancer. The results showed that therapeutic concentration of VPA (50 and 100 mg/kg) delayed the occurrence of tumors, reduced tumor formation rate and attenuated tumors growth, and have a protective effect on normal tissues. The macrophage-mediated inflammatory response was found to be associated with the observed effect of VPA. In addition, we screened and validated a possible gene, , which was involved in DMBA-induced breast cancer development and can be inhibited by VPA.
本研究调查了丙戊酸（VPA，一种组蛋白去乙酰化酶抑制剂）是否能干扰多环芳烃（PAHs）的致癌性。使用PAHs的一种典型代表性化合物7,12-二甲基苯并[a]蒽（DMBA）诱导大鼠乳腺癌。结果表明，治疗浓度的VPA（50和100mg/kg）延迟了肿瘤的发生，降低了肿瘤形成率并减缓了肿瘤生长，且对正常组织有保护作用。发现巨噬细胞介导的炎症反应与VPA的观察效果相关。此外，我们筛选并验证了一个可能的基因，其参与DMBA诱导的乳腺癌发展且可被VPA抑制。
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