• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

宿主和寄生虫株对感染期间免疫反应的影响。

Influence of the Host and Parasite Strain on the Immune Response During Infection.

机构信息

Department of Pathology, Microbiology & Immunology, School of Veterinary Medicine, University of California, Davis, Davis, CA, United States.

出版信息

Front Cell Infect Microbiol. 2020 Oct 15;10:580425. doi: 10.3389/fcimb.2020.580425. eCollection 2020.

DOI:10.3389/fcimb.2020.580425
PMID:33178630
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7593385/
Abstract

is an exceptionally successful parasite that infects a very broad host range, including humans, across the globe. The outcome of infection differs remarkably between hosts, ranging from acute death to sterile infection. These differential disease patterns are strongly influenced by both host- and parasite-specific genetic factors. In this review, we discuss how the clinical outcome of toxoplasmosis varies between hosts and the role of different immune genes and parasite virulence factors, with a special emphasis on induced ileitis and encephalitis.

摘要

刚地弓形虫是一种非常成功的寄生虫，能感染非常广泛的宿主范围，包括全球的人类。感染的结果在宿主之间有显著差异，从急性死亡到无菌感染不等。这些不同的疾病模式强烈受到宿主和寄生虫特异性遗传因素的影响。在这篇综述中，我们讨论了弓形虫病在宿主之间的临床结果如何不同，以及不同的免疫基因和寄生虫毒力因素的作用，特别强调了诱导性回肠炎和脑炎。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3661/7593385/16a0d56deaa9/fcimb-10-580425-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3661/7593385/3695c1c559d7/fcimb-10-580425-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3661/7593385/16a0d56deaa9/fcimb-10-580425-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3661/7593385/3695c1c559d7/fcimb-10-580425-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3661/7593385/16a0d56deaa9/fcimb-10-580425-g0002.jpg

相似文献

1
Influence of the Host and Parasite Strain on the Immune Response During Infection.宿主和寄生虫株对感染期间免疫反应的影响。
Front Cell Infect Microbiol. 2020 Oct 15;10:580425. doi: 10.3389/fcimb.2020.580425. eCollection 2020.
2
The pathogenicity and virulence of . 的致病性和毒力。
Virulence. 2021 Dec;12(1):3095-3114. doi: 10.1080/21505594.2021.2012346.
3
The Toxoplasma gondii Rhoptry Kinome Is Essential for Chronic Infection.刚地弓形虫棒状体激酶组对慢性感染至关重要。
mBio. 2016 May 10;7(3):e00193-16. doi: 10.1128/mBio.00193-16.
4
Strain hypothesis of Toxoplasma gondii infection on the outcome of human diseases.弓形虫感染对人类疾病结局的应激假说。
Acta Physiol (Oxf). 2015 Apr;213(4):828-45. doi: 10.1111/apha.12458. Epub 2015 Jan 28.
5
Dense Granule Proteins 7, 14, and 15 Are Involved in Modification and Control of the Immune Response Mediated via NF-κB Pathway.致密颗粒蛋白 7、14 和 15 参与了通过 NF-κB 通路介导的免疫反应的修饰和控制。
Front Immunol. 2020 Jul 31;11:1709. doi: 10.3389/fimmu.2020.01709. eCollection 2020.
6
Transcriptomic analysis reveals Toxoplasma gondii strain-specific differences in host cell response to dense granule protein GRA15.转录组分析揭示了弓形虫不同菌株在宿主细胞对致密颗粒蛋白GRA15反应中的特异性差异。
Parasitol Res. 2018 Sep;117(9):2785-2793. doi: 10.1007/s00436-018-5966-8. Epub 2018 Jun 19.
7
Toxoplasma gondii superinfection and virulence during secondary infection correlate with the exact ROP5/ROP18 allelic combination.弓形虫二次感染期间的重复感染和毒力与确切的ROP5/ROP18等位基因组合相关。
mBio. 2015 Feb 24;6(2):e02280. doi: 10.1128/mBio.02280-14.
8
Disease Tolerance in Infection.感染中的疾病耐受。
Front Cell Infect Microbiol. 2019 Jun 6;9:185. doi: 10.3389/fcimb.2019.00185. eCollection 2019.
9
Influence of Two Major Virulence Factors (ROP16 and ROP18) on the Immune Response of Peripheral Blood Mononuclear Cells to Human Toxoplasmosis Infection.两种主要毒力因子（ROP16 和 ROP18）对人弓形虫感染外周血单个核细胞免疫反应的影响。
Front Cell Infect Microbiol. 2019 Dec 4;9:413. doi: 10.3389/fcimb.2019.00413. eCollection 2019.
10
IFNs in host defence and parasite immune evasion during infections.IFNs 在感染期间宿主防御和寄生虫免疫逃避中的作用。
Front Immunol. 2024 Feb 7;15:1356216. doi: 10.3389/fimmu.2024.1356216. eCollection 2024.

引用本文的文献

1
First isolation of viable Toxoplasma gondii from a black mangabey (Lophocebus aterrimus) reveals the emergence of the Africa 1 lineage in East Asia.首次从黑冠白睑猴（Lophocebus aterrimus）中分离出活的刚地弓形虫，揭示了非洲1谱系在东亚的出现。
PLoS Negl Trop Dis. 2025 Jul 23;19(7):e0013133. doi: 10.1371/journal.pntd.0013133. eCollection 2025 Jul.
2
Unveiling the therapeutic potential of natural products in Alzheimer's disease: insights from , , and clinical studies.揭示天然产物在阿尔茨海默病中的治疗潜力：来自……及临床研究的见解
Front Pharmacol. 2025 Jun 23;16:1601712. doi: 10.3389/fphar.2025.1601712. eCollection 2025.
3

本文引用的文献

1
Naïve CD8 T cell IFNγ responses to a vacuolar antigen are regulated by an inflammasome-independent NLRP3 pathway and Toxoplasma gondii ROP5.幼稚 CD8 T 细胞对空泡抗原的 IFNγ 应答受一种炎症小体非依赖的 NLRP3 途径和刚地弓形虫 ROP5 的调控。
PLoS Pathog. 2020 Aug 27;16(8):e1008327. doi: 10.1371/journal.ppat.1008327. eCollection 2020 Aug.
2
Toxoplasma  GRA15 and GRA24 are important activators of the host innate immune response in the absence of TLR11.弓形虫 GRA15 和 GRA24 在缺乏 TLR11 的情况下是宿主固有免疫反应的重要激活剂。
PLoS Pathog. 2020 May 26;16(5):e1008586. doi: 10.1371/journal.ppat.1008586. eCollection 2020 May.
3
Early dynamics of Toxoplasma gondii infection in sheep inoculated at mid-gestation with archetypal type II oocysts.
妊娠中期接种原型II型卵囊的绵羊弓形虫感染的早期动态变化
Vet Res. 2025 Jul 1;56(1):134. doi: 10.1186/s13567-025-01557-1.
4
Acetaminophen, a new tool for the refinement of the experimental infection of toxoplasmosis in mice.对乙酰氨基酚，一种用于优化小鼠弓形虫病实验性感染的新工具。
Sci Rep. 2025 Jul 1;15(1):22157. doi: 10.1038/s41598-025-06849-2.
5
Phytochemical content of Cycas rumphii n-butanol fraction and antiprotozoal activity against Toxoplasma gondii in vivo.苏铁正丁醇部位的植物化学成分及其对刚地弓形虫的体内抗寄生虫活性。
Sci Rep. 2025 May 5;15(1):15697. doi: 10.1038/s41598-025-98993-y.
6
Treatment with BKI-1748 after systemic dissemination in experimentally infected pregnant sheep improves fetal and lamb mortality and morbidity and prevents congenital infection.在实验性感染的怀孕绵羊全身播散后用BKI-1748进行治疗可改善胎儿和羔羊的死亡率及发病率，并预防先天性感染。
Antimicrob Agents Chemother. 2025 Feb 13;69(2):e0144824. doi: 10.1128/aac.01448-24. Epub 2024 Dec 31.
7
Editorial: Rising stars in parasite and host: 2023.社论：寄生虫与宿主领域的后起之秀：2023年。
Front Cell Infect Microbiol. 2024 Dec 2;14:1509107. doi: 10.3389/fcimb.2024.1509107. eCollection 2024.
8
Editorial: Intraspecies variability in apicomplexan parasites: epidemiology, traits and virulence.社论：顶复门寄生虫的种内变异性：流行病学、特征与毒力
Front Cell Infect Microbiol. 2024 Oct 16;14:1497043. doi: 10.3389/fcimb.2024.1497043. eCollection 2024.
9
The emerging role of in periodontal diseases and underlying mechanisms.在牙周病中的新兴作用及其潜在机制。
Front Immunol. 2024 Oct 3;15:1464108. doi: 10.3389/fimmu.2024.1464108. eCollection 2024.
10
Adaptations and metabolic evolution of myzozoan protists across diverse lifestyles and environments.跨多种生活方式和环境的动基体目原生生物的适应性与代谢进化
Microbiol Mol Biol Rev. 2024 Dec 18;88(4):e0019722. doi: 10.1128/mmbr.00197-22. Epub 2024 Oct 10.
Toxoplasma gondii dense granule protein GRA24 drives MyD88-independent p38 MAPK activation, IL-12 production and induction of protective immunity.
刚地弓形虫致密颗粒蛋白 GRA24 驱动 MyD88 非依赖性 p38 MAPK 的激活、IL-12 的产生和诱导保护性免疫。
PLoS Pathog. 2020 May 15;16(5):e1008572. doi: 10.1371/journal.ppat.1008572. eCollection 2020 May.
4
Toxoplasma GRA15 limits parasite growth in IFNγ-activated fibroblasts through TRAF ubiquitin ligases.弓形虫 GRA15 通过 TRAF 泛素连接酶限制 IFNγ 激活的成纤维细胞中的寄生虫生长。
EMBO J. 2020 May 18;39(10):e103758. doi: 10.15252/embj.2019103758. Epub 2020 Apr 15.
5
infection and toxoplasmosis in farm animals: Risk factors and economic impact.农场动物的感染与弓形虫病：风险因素及经济影响
Food Waterborne Parasitol. 2019 Apr 3;15:e00037. doi: 10.1016/j.fawpar.2019.e00037. eCollection 2019 Jun.
6
The Toxoplasma gondii virulence factor ROP16 acts in cis and trans, and suppresses T cell responses.刚地弓形虫毒力因子 ROP16 顺式和反式作用，抑制 T 细胞应答。
J Exp Med. 2020 Mar 2;217(3). doi: 10.1084/jem.20181757.
7
Neuroinflammation-Associated Aspecific Manipulation of Mouse Predator Fear by Toxoplasma gondii.弓形虫对小鼠捕食者恐惧的神经炎症相关非特异性操纵。
Cell Rep. 2020 Jan 14;30(2):320-334.e6. doi: 10.1016/j.celrep.2019.12.019.
8
Serotyping of Infection Using Peptide Membrane Arrays.利用肽膜阵列进行感染的血清分型。
Front Cell Infect Microbiol. 2019 Nov 29;9:408. doi: 10.3389/fcimb.2019.00408. eCollection 2019.
9
Innate, adaptive, and cell-autonomous immunity against Toxoplasma gondii infection.先天性免疫、适应性免疫和细胞自主免疫对抗弓形虫感染。
Exp Mol Med. 2019 Dec 11;51(12):1-10. doi: 10.1038/s12276-019-0353-9.
10
Dolphin-derived NETosis results in rapid Toxoplasma gondii tachyzoite ensnarement and different phenotypes of NETs.海豚来源的细胞 NETosis 导致速殖子被迅速捕获，以及 NET 不同表型。
Dev Comp Immunol. 2020 Feb;103:103527. doi: 10.1016/j.dci.2019.103527. Epub 2019 Oct 23.