小胶质细胞在视觉回路精炼过程中调整视网膜神经节细胞通路。
Microglia Tweak Retinogeniculate Pathways during Visual Circuit Refinement.
机构信息
Department of Neuroscience, Physiology and Pharmacology, University College London, 21 University St., London WC1E 6DE, UK.
出版信息
Neuron. 2020 Nov 11;108(3):397-399. doi: 10.1016/j.neuron.2020.10.018.
PMID:33181071
Abstract
Cheadle et al. reveal that microglia expressing TWEAK facilitate synapse elimination through a novel, non-phagocytic mechanism in the retinogeniculate pathway during visual circuit development. This mechanism is experience-dependent and occurs through the local binding of TWEAK to postsynaptic Fn14.
摘要
切德尔等人揭示了在视觉回路发育过程中，表达 TWEAK 的小胶质细胞通过视网膜-视放射通路上的一种新型非吞噬作用机制促进突触消除。这种机制是经验依赖性的，通过 TWEAK 与突触后 Fn14 的局部结合来实现。
Zotero 插件