生长激素信号转导：受体激活和降解机制。

GHR signalling: Receptor activation and degradation mechanisms.

机构信息

The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD, 4102, Australia; Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21231, USA.

The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD, 4102, Australia.

出版信息

Mol Cell Endocrinol. 2021 Jan 15;520:111075. doi: 10.1016/j.mce.2020.111075. Epub 2020 Nov 9.

DOI:10.1016/j.mce.2020.111075

PMID:33181235

Abstract

Growth hormone (GH) actions via initiating cell signalling through the GH receptor (GHR) are important for many physiological processes, in addition to its well-known role in regulating growth. The activation of JAK-STAT signalling by GH is well characterized, however knowledge on GH activation of SRC family kinases (SFKs) is still limited. In this review we summarise the collective knowledge on the activation, regulation, and downstream signalling of GHR. We highlight studies on GH activation of SFKs and the important outcome of this signalling pathway with a focus on the different degradation mechanisms that can regulate GHR availability since this is an area that warrants further study considering its role in tumour progression.

摘要

生长激素（GH）通过生长激素受体（GHR）启动细胞信号转导的作用对于许多生理过程都很重要，除了其在调节生长方面的众所周知的作用。GH 对 JAK-STAT 信号转导的激活已得到很好的描述，但是关于 GH 对 SRC 家族激酶（SFKs）的激活的知识仍然有限。在这篇综述中，我们总结了关于 GHR 的激活、调节和下游信号转导的综合知识。我们重点介绍了 GH 对 SFKs 的激活以及该信号通路的重要结果的研究，特别关注不同的降解机制，因为这些机制可以调节 GHR 的可用性，考虑到其在肿瘤进展中的作用，这是一个值得进一步研究的领域。