布洛芬预防急性高原病：一项系统评价和荟萃分析方案
Prophylaxis of ibuprofen in acute mountain sickness: A protocol for systematic review and meta-analysis.
作者信息
Yi Hai, Wang Kuiying, Gan Xinyu, Li Li, Zhang Qian, Xiang Jiao, Yuan Xiuwei, Zhang Yugang, Wang Yonghua
机构信息
Department of Hematology.
Department of Wounded Management.
出版信息
Medicine (Baltimore). 2020 Nov 13;99(46):e23233. doi: 10.1097/MD.0000000000023233.
BACKGROUND
Acute mountain sickness (AMS) is the effect when people accessing high altitude in a short period of time. As a cyclooxygenase (COX) inhibitor, ibuprofen could alleviate the symptoms of AMS. However, whether it can prevent AMS or not is still controversial. It is necessary to perform a meta-analysis to evaluate the role of ibuprofen in AMS prophylaxis.
METHODS
PubMed, EMBASE, Medline, ISI Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI) will be searched for the relevant published studies that explored the value of ibuprofen in AMS prophylaxis from inception to October 2020. The data will be independently extracted by 2 researchers. Risk of bias will be evaluated based on Cochrane risk of bias assessment tool. Heterogeneity among the included studies will be evaluated by χ and I values. The meta-analysis was conducted by RevMan software version 5.3.
RESULTS
This study will evaluate the role of ibuprofen in AMS prophylaxis.
CONCLUSION
This study will summarize the current evidence of ibuprofen in AMS prophylaxis, which could further guide the recommendation in prevention of AMS.Open Science Framework (OSF) registration number: October 8, 2020. osf.io/n3mjt.
背景
急性高原病（AMS）是人们在短时间内进入高海拔地区时出现的一种反应。作为一种环氧化酶（COX）抑制剂，布洛芬可以缓解急性高原病的症状。然而，它是否能预防急性高原病仍存在争议。有必要进行一项荟萃分析来评估布洛芬在预防急性高原病中的作用。
方法
将检索PubMed、EMBASE、Medline、ISI Web of Science、Cochrane图书馆、中国知网（CNKI），以查找从创刊至2020年10月探索布洛芬在预防急性高原病中价值的相关已发表研究。数据将由两名研究人员独立提取。将根据Cochrane偏倚风险评估工具评估偏倚风险。纳入研究之间的异质性将通过χ²和I²值进行评估。荟萃分析采用RevMan 5.3软件进行。
结果
本研究将评估布洛芬在预防急性高原病中的作用。
结论
本研究将总结目前布洛芬在预防急性高原病方面的证据，这可能进一步指导急性高原病预防方面的建议。开放科学框架（OSF）注册号：2020年10月8日。osf.io/n3mjt。
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