中枢神经系统胚胎性肿瘤综合诊断报告的组织病理学和分子特征。
Histopathologic and Molecular Features of Central Nervous System Embryonal Tumors for Integrated Diagnosis Reporting.
机构信息
Department of Laboratories, Seattle Children's Hospital, OC.8.720, 4800 Sand Point Way Northeast, 1959 NE Pacific St., Box 357470, Seattle, WA 98105, USA; Department of Anatomic Pathology, University of Washington School of Medicine, 1959 NE Pacific St., Box 357470, Seattle, WA 98195, USA.
Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, J0359, 700 Children's Drive, Columbus, OH 43205, USA; Department of Pathology, The Ohio State University, 129 Hamilton Hall, 1645 Neil Avenue, Columbus, OH 43210, USA; Department of Biomedical Education & Anatomy, The Ohio State University, 1645 Neil Avenue, Columbus, OH 43210, USA.
出版信息
Surg Pathol Clin. 2020 Dec;13(4):783-800. doi: 10.1016/j.path.2020.08.005. Epub 2020 Oct 9.
Embryonal tumors of the pediatric central nervous system are challenging clinically and diagnostically. These tumors are aggressive, and patients often have poor outcomes even with intense therapy. Proper tumor classification is essential to patient care, and this process has undergone significant changes with the World Health Organization recommending histopathologic and molecular features be integrated in diagnostic reporting. This has especially impacted the workup of embryonal tumors because molecular testing has resulted in the identification of clinically relevant tumor subgroups and new entities. This review summarizes recent developments and provides a framework to workup embryonal tumors in diagnostic practice.
儿科中枢神经系统胚胎性肿瘤在临床上具有挑战性，诊断上也具有难度。这些肿瘤具有侵袭性，即使接受强化治疗，患者的预后通常也较差。正确的肿瘤分类对于患者的治疗至关重要，这一过程随着世界卫生组织建议将组织病理学和分子特征整合到诊断报告中而发生了重大变化。这对胚胎性肿瘤的检查尤其具有影响，因为分子检测已经确定了具有临床意义的肿瘤亚群和新实体。本文总结了最新进展，并为诊断实践中胚胎性肿瘤的检查提供了一个框架。
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