SPRTN 蛋白酶调控的三位一体。

The Trinity of SPRTN Protease Regulation.

机构信息

Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Roosevelt Drive, OX3 7DQ, Oxford, UK.

出版信息

Trends Biochem Sci. 2021 Jan;46(1):2-4. doi: 10.1016/j.tibs.2020.10.007. Epub 2020 Nov 9.

DOI:10.1016/j.tibs.2020.10.007

PMID:33183910

Abstract

The protease SPRTN emerged as the essential enzyme for DNA-protein crosslink proteolysis repair. Biochemical and cell biological work indicated that SPRTN is a nonspecific protease. Recent and independent studies from Lou, Stingele, and Ramadan reveal that SPRTN activity is modulated via three layers of regulation that make it selective for DNA-protein crosslinks.

摘要

蛋白酶 SPRTN 是 DNA-蛋白质交联蛋白水解修复的必需酶。生化和细胞生物学研究表明，SPRTN 是一种非特异性蛋白酶。最近 Lou、Stingele 和 Ramadan 的独立研究揭示了 SPRTN 活性通过三层调节来调节，使其对 DNA-蛋白质交联具有选择性。